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Chemical Structure| 64989-74-8 Chemical Structure| 64989-74-8

Structure of 64989-74-8

Chemical Structure| 64989-74-8

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Product Details of [ 64989-74-8 ]

CAS No. :64989-74-8
Formula : C10H10ClFN2O2
M.W : 244.65
SMILES Code : O=C(OCC)/C(Cl)=N/NC1=CC=CC=C1F
MDL No. :MFCD06658069

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Application In Synthesis of [ 64989-74-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64989-74-8 ]

[ 64989-74-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 545445-44-1 ]
  • [ 64989-74-8 ]
  • C26H25FN4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
67.9% With triethylamine; In ethyl acetate; at 80℃;Inert atmosphere; The 1g (280mg, 0.79mmol) was dissolved in ethyl acetate (10ml), and at room temperature was added [(2-fluorophenyl)hydrazono]chloroacetic acid ethyl ester(255mg, 1.04mmol), triethylamine (242mg, 2.4 mmol) to give a reaction mixture, and the reaction mixture was refluxed overnight at 80 C . Tracking progress of the reaction by TLC, after completion of the reaction, at room temperature was slowly added dropwise 4N HCl (1.6ml) to give a reaction mixture, said reaction mixture at room temperature overnight. Thin-layer chromatography to track progress of the reaction, the reaction was complete, was purified by column chromatography 3h (255mg, yellow solid), yield: 67.9%
 

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