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Chemical Structure| 6490-42-2 Chemical Structure| 6490-42-2
Chemical Structure| 6490-42-2

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1-Ethylpyrimidine-2,4(1H,3H)-dione

CAS No.: 6490-42-2

4.5 *For Research Use Only !

Cat. No.: A314887 Purity: 97%

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Product Details of [ 6490-42-2 ]

CAS No. :6490-42-2
Formula : C6H8N2O2
M.W : 140.14
SMILES Code : O=C1NC(C=CN1CC)=O
MDL No. :MFCD00136723
Boiling Point : No data available
InChI Key :KPLDRYODCDLNHB-UHFFFAOYSA-N
Pubchem ID :4183135

Safety of [ 6490-42-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis [ 6490-42-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6490-42-2 ]

[ 6490-42-2 ] Synthesis Path-Downstream   1~25

  • 2
  • [ 6490-42-2 ]
  • [ 563-79-1 ]
  • 2-ethyl-7,7,8,8-tetramethyl-cis-2,4-diazabicyclo<4.2.0>octane-3,5-dione [ No CAS ]
  • 3
  • [ 6490-42-2 ]
  • [ 36387-90-3 ]
  • 4
  • [ 6490-42-2 ]
  • 5-Bromo-1-ethyl-dihydro-pyrimidine-2,4-dione [ No CAS ]
  • [ 36387-90-3 ]
  • 5
  • [ 7424-91-1 ]
  • [ 625-52-5 ]
  • [ 6490-42-2 ]
  • 6
  • [ 75-03-6 ]
  • [ 66-22-8 ]
  • [ 6490-42-2 ]
  • [ 22390-04-1 ]
  • 7
  • [ 113808-32-5 ]
  • [ 66-22-8 ]
  • [ 6490-42-2 ]
  • [ 113808-29-0 ]
  • 8
  • [ 113808-27-8 ]
  • [ 10457-14-4 ]
  • [ 6490-42-2 ]
  • [ 113808-29-0 ]
  • 9
  • [ 6490-42-2 ]
  • 6-Ethyl-6H-tetrazolo[1,5-c]pyrimidin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
14.0 g (20%) EXAMPLE 36 44 Grams of N-ethylurea and 105 g of β,β-diethoxypropionic acid ethyl ester were added to a solution of 15.0 g of sodium in 700 ml of ethanol. The yellow solution was then heated for 3 hours at 25 and subsequently boiled under reflux for 15 hours. The mixture was evaporated in vacuo and the residue dissolved in 300 ml of water, cooled to 0 and acidified with 100 ml of concentrated hydrochloric acid. A crystalline intermediate precipitated out (43 g) and was filtered off under vacuum, washed with 100 ml of ice-water and subsequently heated to 80-100 in 250 ml of water until conversion into the desired water-soluble 1-ethyl-uracil is complete. The solution was evaporated in vacuo at 40 and the remaining residue recrystallized from ethanol/ether; yield 14.0 g (20%) of colorless 1-ethyl-uracil; melting point 150 C.
  • 12
  • [ 71-30-7 ]
  • [ 75-04-7 ]
  • [ 6490-42-2 ]
  • [ 25855-37-2 ]
  • 13
  • [ 75-04-7 ]
  • [ 66-22-8 ]
  • [ 6490-42-2 ]
  • 15
  • [ 25855-36-1 ]
  • [ 6490-42-2 ]
  • 16
  • [ 18002-25-0 ]
  • [ 64-67-5 ]
  • 2-ethoxy-4-methoxypyrimidine [ No CAS ]
  • [ 6490-42-2 ]
  • [ 22390-04-1 ]
  • [ 25902-94-7 ]
  • 17
  • [ 64-67-5 ]
  • [ 66-22-8 ]
  • 2-ethoxy-3-ethyl-2(3H)-pyrimidinone [ No CAS ]
  • [ 6490-42-2 ]
  • [ 5148-09-4 ]
  • [ 25902-95-8 ]
  • 18
  • [ 6490-42-2 ]
  • [ 50-00-0 ]
  • C13H16N4O4 [ No CAS ]
  • 19
  • [ 6490-42-2 ]
  • [ 66-99-9 ]
  • C23H22N4O4 [ No CAS ]
  • 20
  • 1-[(E)-3-Dimethylamino-1-methylsulfanyl-prop-2-en-(E)-ylidene]-3-ethyl-urea [ No CAS ]
  • [ 6490-42-2 ]
  • 21
  • [ 6490-42-2 ]
  • 2-N hydrochloric acid [ No CAS ]
  • [ 58-71-9 ]
  • [ 58909-55-0 ]
  • [ 767230-97-7 ]
  • [ 58909-53-8 ]
YieldReaction ConditionsOperation in experiment
3.5 g (42%) With pyridine; diphosphorus pentasulfide; In ethanol; water; acetic acid; Chlorine was led into a solution of 9.9 g of 1-ethyl-uracil in 150 ml of glacial acetic acid until iodine-potassium-starch paper reacted positively and 1-ethyl-uracil was no longer detectable by thin-layer chromatography (ca. 0.5 hours). The mixture was evaporated in vacuo at 40 and the crystalline residue recrystallized from 300 ml of ethanol; yield 10.0 g (81%) of colorless, fine needles of 1-ethyl-5-chlorouracil; melting point 244-247. 1.74 Grams of 1-ethyl-5-chlorouracil were mixed with 4.44 g of phosphorus pentasulfide and 0.1 ml of water and the mixture treated with 30 ml of pyridine and boiled at reflux for 3.75 hours. The mixture was then evaporated in vacuo at 40, the residue suspended in 30 ml of water and treated with 30 ml of 2-N hydrochloric acid. the crystals obtained were filtered off under suction, washed with water and recrystallized from 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine; melting point 217-220. In a manner analogous to that described in Example 1 6.27 g of cephalothin sodium salt were reacted 3.04 g of 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine prepared above to give (7R)-3-[[(1-ethyl-5-chloro-1,2-dihydro-2-oxo-4-pyrimidinyl)-thio]methyl]-7-[2-(2-thienyl)-acetamido]-3-cephem-4-carboxylic acid as the sodium salt; yield 3.5 g (42%); melting point from 185 (decomposition); [α]D20 = -95.2 (c = 0.394 in water).
  • 22
  • cis-diaminediiodoplatinum(II) [ No CAS ]
  • [ 6490-42-2 ]
  • cis-[Pt(1-ethyluracilate)2(NH3)2] [ No CAS ]
  • 23
  • [ 6490-42-2 ]
  • cis-[Pt2(1-ethyluracilate)2(NH3)4](NO3)2 [ No CAS ]
  • 24
  • [ 75-03-6 ]
  • [ 66-22-8 ]
  • [ 6490-42-2 ]
  • [ 5148-09-4 ]
  • [ 22390-04-1 ]
  • [ 25902-95-8 ]
  • 25
  • [ 66-22-8 ]
  • ethyl halide [ No CAS ]
  • [ 6490-42-2 ]
  • [ 22390-04-1 ]
 

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