[ CAS No. 6490-42-2 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 6490-42-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 6490-42-2 ]

SDS Specification

Alternatived Products of [ 6490-42-2 ]

Product Details of [ 6490-42-2 ]

CAS No. :	6490-42-2	MDL No. :	MFCD00136723
Formula :	C₆H₈N₂O₂	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	KPLDRYODCDLNHB-UHFFFAOYSA-N
M.W :	140.14	Pubchem ID :	4183135
Synonyms :

Safety of [ 6490-42-2 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 6490-42-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6490-42-2 ]

[ 6490-42-2 ] Synthesis Path-Downstream 1~22

1
[ 25902-95-8 ]
[ 6490-42-2 ]

Reference： [1]Journal of the American Chemical Society,1937,vol. 59,p. 330,333

2
[ 6490-42-2 ]
[ 563-79-1 ]
2-ethyl-7,7,8,8-tetramethyl-cis-2,4-diazabicyclo<4.2.0>octane-3,5-dione [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1991,vol. 39,p. 1922 - 1930

3
[ 6490-42-2 ]
[ 36387-90-3 ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 1117 - 1121

4
[ 6490-42-2 ]
5-Bromo-1-ethyl-dihydro-pyrimidine-2,4-dione [ No CAS ]
[ 36387-90-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1993,p. 1487 - 1490

5
[ 7424-91-1 ]
[ 625-52-5 ]
[ 6490-42-2 ]

Reference： [1]Synthesis,1986,p. 1041 - 1044

6
[ 75-03-6 ]
[ 66-22-8 ]
[ 6490-42-2 ]
[ 22390-04-1 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1991,vol. 39,p. 1922 - 1930

7
[ 113808-32-5 ]
[ 66-22-8 ]
[ 6490-42-2 ]
[ 113808-29-0 ]

Reference： [1]Tetrahedron Letters,1987,vol. 28,p. 3623 - 3626

8
[ 113808-27-8 ]
[ 10457-14-4 ]
[ 6490-42-2 ]
[ 113808-29-0 ]

Reference： [1]Collection of Czechoslovak Chemical Communications,1989,vol. 54,p. 1055 - 1066

9
[ 6490-42-2 ]
6-Ethyl-6H-tetrazolo[1,5-c]pyrimidin-5-one [ No CAS ]

Reference： [1]Synthesis,1995,p. 777 - 779

Yield	Reaction Conditions	Operation in experiment
14.0 g (20%)		EXAMPLE 36 44 Grams of N-ethylurea and 105 g of β,β-diethoxypropionic acid ethyl ester were added to a solution of 15.0 g of sodium in 700 ml of ethanol. The yellow solution was then heated for 3 hours at 25 and subsequently boiled under reflux for 15 hours. The mixture was evaporated in vacuo and the residue dissolved in 300 ml of water, cooled to 0 and acidified with 100 ml of concentrated hydrochloric acid. A crystalline intermediate precipitated out (43 g) and was filtered off under vacuum, washed with 100 ml of ice-water and subsequently heated to 80-100 in 250 ml of water until conversion into the desired water-soluble 1-ethyl-uracil is complete. The solution was evaporated in vacuo at 40 and the remaining residue recrystallized from ethanol/ether; yield 14.0 g (20%) of colorless 1-ethyl-uracil; melting point 150 C.

12
[ 71-30-7 ]
[ 75-04-7 ]
[ 6490-42-2 ]
[ 25855-37-2 ]

Reference： [1]Photochemistry and Photobiology,2000,vol. 71,p. 243 - 253

13
[ 75-04-7 ]
[ 66-22-8 ]
[ 6490-42-2 ]

Reference： [1]Photochemistry and Photobiology,2000,vol. 71,p. 243 - 253

14
[ 316352-69-9 ]
[ 6490-42-2 ]

Reference： [1]Organic Preparations and Procedures International,2001,vol. 33,p. 400 - 405

15
[ 25855-36-1 ]
[ 6490-42-2 ]

Reference： [1]European Journal of Organic Chemistry,2006,p. 634 - 643

16
[ 18002-25-0 ]
[ 64-67-5 ]
2-ethoxy-4-methoxypyrimidine [ No CAS ]
[ 6490-42-2 ]
[ 22390-04-1 ]
[ 25902-94-7 ]

Reference： [1]Tetrahedron,2006,vol. 62,p. 6848 - 6854

17
[ 64-67-5 ]
[ 66-22-8 ]
2-ethoxy-3-ethyl-2(3H)-pyrimidinone [ No CAS ]
[ 6490-42-2 ]
[ 5148-09-4 ]
[ 25902-95-8 ]

Reference： [1]Tetrahedron,2006,vol. 62,p. 6848 - 6854

18
[ 6490-42-2 ]
[ 50-00-0 ]
C₁₃H₁₆N₄O₄ [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 8483 - 8487

19
[ 6490-42-2 ]
[ 66-99-9 ]
C₂₃H₂₂N₄O₄ [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 8483 - 8487

20
1-[(E)-3-Dimethylamino-1-methylsulfanyl-prop-2-en-(E)-ylidene]-3-ethyl-urea [ No CAS ]
[ 6490-42-2 ]

Reference： [1]European Journal of Organic Chemistry,2006,p. 634 - 643

21
[ 6490-42-2 ]
2-N hydrochloric acid [ No CAS ]
[ 58-71-9 ]
[ 58909-55-0 ]
[ 767230-97-7 ]
[ 58909-53-8 ]

Yield	Reaction Conditions	Operation in experiment
3.5 g (42%)	With pyridine; diphosphorus pentasulfide; In ethanol; water; acetic acid;	Chlorine was led into a solution of 9.9 g of 1-ethyl-uracil in 150 ml of glacial acetic acid until iodine-potassium-starch paper reacted positively and 1-ethyl-uracil was no longer detectable by thin-layer chromatography (ca. 0.5 hours). The mixture was evaporated in vacuo at 40 and the crystalline residue recrystallized from 300 ml of ethanol; yield 10.0 g (81%) of colorless, fine needles of 1-ethyl-5-chlorouracil; melting point 244-247. 1.74 Grams of 1-ethyl-5-chlorouracil were mixed with 4.44 g of phosphorus pentasulfide and 0.1 ml of water and the mixture treated with 30 ml of pyridine and boiled at reflux for 3.75 hours. The mixture was then evaporated in vacuo at 40, the residue suspended in 30 ml of water and treated with 30 ml of 2-N hydrochloric acid. the crystals obtained were filtered off under suction, washed with water and recrystallized from 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine; melting point 217-220. In a manner analogous to that described in Example 1 6.27 g of cephalothin sodium salt were reacted 3.04 g of 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine prepared above to give (7R)-3-[[(1-ethyl-5-chloro-1,2-dihydro-2-oxo-4-pyrimidinyl)-thio]methyl]-7-[2-(2-thienyl)-acetamido]-3-cephem-4-carboxylic acid as the sodium salt; yield 3.5 g (42%); melting point from 185 (decomposition); [α]D20 = -95.2 (c = 0.394 in water).

Reference： [1]Patent: US4091211,1978,A

22
cis-diaminediiodoplatinum(II) [ No CAS ]
[ 6490-42-2 ]
cis-[Pt(1-ethyluracilate)2(NH₃)2] [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1997,vol. 263,p. 69 - 79

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[ 6490-42-2 ]

Amides

[ 874-14-6 ]

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[ 615-77-0 ]

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[ 3055-23-0 ]

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Related Parent Nucleus of
[ 6490-42-2 ]

Pyrimidines

[ 40338-28-1 ]

1-Acetylpyrimidine-2,4(1H,3H)-dione

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1,3-Dimethylpyrimidine-2,4(1H,3H)-dione

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1-Methylpyrimidine-2,4(1H,3H)-dione

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2,4-Dioxo-3,4-dihydropyrimidine-1(2H)-carbaldehyde

Similarity: 0.98

[ 3055-23-0 ]

2-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetaldehyde

Similarity: 0.95

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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
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P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
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H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6490-42-2 ] {[proInfo.proName]}

Quality Control of [ 6490-42-2 ]

Related Doc. of [ 6490-42-2 ]

Product Details of [ 6490-42-2 ]

Safety of [ 6490-42-2 ]

Application In Synthesis of [ 6490-42-2 ]

[ 6490-42-2 ] Synthesis Path-Downstream 1~22

Related Functional Groups of [ 6490-42-2 ]

Amides

Related Parent Nucleus of [ 6490-42-2 ]

Pyrimidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 6490-42-2 ]

Related Parent Nucleus of
[ 6490-42-2 ]