[ CAS No. 6490-42-2 ] {[proInfo.proName]}

Name: 6490-42-2|1-Ethylpyrimidine-2,4(1H,3H)-dione|97%
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SKU: A314887
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Quality Control of [ 6490-42-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 6490-42-2 ]

CAS No. :	6490-42-2	MDL No. :	MFCD00136723
Formula :	C₆H₈N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	KPLDRYODCDLNHB-UHFFFAOYSA-N
M.W :	140.14	Pubchem ID :	4183135
Synonyms :

Safety of [ 6490-42-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6490-42-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6490-42-2 ]

[ 6490-42-2 ] Synthesis Path-Downstream 1~33

1
[ 25902-95-8 ]
[ 6490-42-2 ]

Reference： [1]Journal of the American Chemical Society,1937,vol. 59,p. 330,333

2
[ 6490-42-2 ]
[ 563-79-1 ]
2-ethyl-7,7,8,8-tetramethyl-cis-2,4-diazabicyclo<4.2.0>octane-3,5-dione [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1991,vol. 39,p. 1922 - 1930

3
[ 6490-42-2 ]
[ 36387-90-3 ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 1117 - 1121

4
[ 6490-42-2 ]
5-Bromo-1-ethyl-dihydro-pyrimidine-2,4-dione [ No CAS ]
[ 36387-90-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1993,p. 1487 - 1490

5
[ 7424-91-1 ]
[ 625-52-5 ]
[ 6490-42-2 ]

Reference： [1]Synthesis,1986,p. 1041 - 1044

6
[ 75-03-6 ]
[ 66-22-8 ]
[ 6490-42-2 ]
[ 22390-04-1 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1991,vol. 39,p. 1922 - 1930

7
[ 113808-32-5 ]
[ 66-22-8 ]
[ 6490-42-2 ]
[ 113808-29-0 ]

Reference： [1]Tetrahedron Letters,1987,vol. 28,p. 3623 - 3626

8
[ 113808-27-8 ]
[ 10457-14-4 ]
[ 6490-42-2 ]
[ 113808-29-0 ]

Reference： [1]Collection of Czechoslovak Chemical Communications,1989,vol. 54,p. 1055 - 1066

9
[ 6490-42-2 ]
6-Ethyl-6H-tetrazolo[1,5-c]pyrimidin-5-one [ No CAS ]

Reference： [1]Synthesis,1995,p. 777 - 779

Yield	Reaction Conditions	Operation in experiment
14.0 g (20%)		EXAMPLE 36 44 Grams of N-ethylurea and 105 g of β,β-diethoxypropionic acid ethyl ester were added to a solution of 15.0 g of sodium in 700 ml of ethanol. The yellow solution was then heated for 3 hours at 25 and subsequently boiled under reflux for 15 hours. The mixture was evaporated in vacuo and the residue dissolved in 300 ml of water, cooled to 0 and acidified with 100 ml of concentrated hydrochloric acid. A crystalline intermediate precipitated out (43 g) and was filtered off under vacuum, washed with 100 ml of ice-water and subsequently heated to 80-100 in 250 ml of water until conversion into the desired water-soluble 1-ethyl-uracil is complete. The solution was evaporated in vacuo at 40 and the remaining residue recrystallized from ethanol/ether; yield 14.0 g (20%) of colorless 1-ethyl-uracil; melting point 150 C.

12
[ 71-30-7 ]
[ 75-04-7 ]
[ 6490-42-2 ]
[ 25855-37-2 ]

Reference： [1]Photochemistry and Photobiology,2000,vol. 71,p. 243 - 253

13
[ 75-04-7 ]
[ 66-22-8 ]
[ 6490-42-2 ]

Reference： [1]Photochemistry and Photobiology,2000,vol. 71,p. 243 - 253

14
[ 316352-69-9 ]
[ 6490-42-2 ]

Reference： [1]Organic Preparations and Procedures International,2001,vol. 33,p. 400 - 405

15
[ 25855-36-1 ]
[ 6490-42-2 ]

Reference： [1]European Journal of Organic Chemistry,2006,p. 634 - 643

16
[ 18002-25-0 ]
[ 64-67-5 ]
2-ethoxy-4-methoxypyrimidine [ No CAS ]
[ 6490-42-2 ]
[ 22390-04-1 ]
[ 25902-94-7 ]

Reference： [1]Tetrahedron,2006,vol. 62,p. 6848 - 6854

17
[ 64-67-5 ]
[ 66-22-8 ]
2-ethoxy-3-ethyl-2(3H)-pyrimidinone [ No CAS ]
[ 6490-42-2 ]
[ 5148-09-4 ]
[ 25902-95-8 ]

Reference： [1]Tetrahedron,2006,vol. 62,p. 6848 - 6854

18
[ 6490-42-2 ]
[ 50-00-0 ]
C₁₃H₁₆N₄O₄ [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 8483 - 8487

19
[ 6490-42-2 ]
[ 66-99-9 ]
C₂₃H₂₂N₄O₄ [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 8483 - 8487

20
1-[(E)-3-Dimethylamino-1-methylsulfanyl-prop-2-en-(E)-ylidene]-3-ethyl-urea [ No CAS ]
[ 6490-42-2 ]

Reference： [1]European Journal of Organic Chemistry,2006,p. 634 - 643

21
[ 6490-42-2 ]
2-N hydrochloric acid [ No CAS ]
[ 58-71-9 ]
[ 58909-55-0 ]
[ 767230-97-7 ]
[ 58909-53-8 ]

Yield	Reaction Conditions	Operation in experiment
3.5 g (42%)	With pyridine; diphosphorus pentasulfide; In ethanol; water; acetic acid;	Chlorine was led into a solution of 9.9 g of 1-ethyl-uracil in 150 ml of glacial acetic acid until iodine-potassium-starch paper reacted positively and 1-ethyl-uracil was no longer detectable by thin-layer chromatography (ca. 0.5 hours). The mixture was evaporated in vacuo at 40 and the crystalline residue recrystallized from 300 ml of ethanol; yield 10.0 g (81%) of colorless, fine needles of 1-ethyl-5-chlorouracil; melting point 244-247. 1.74 Grams of 1-ethyl-5-chlorouracil were mixed with 4.44 g of phosphorus pentasulfide and 0.1 ml of water and the mixture treated with 30 ml of pyridine and boiled at reflux for 3.75 hours. The mixture was then evaporated in vacuo at 40, the residue suspended in 30 ml of water and treated with 30 ml of 2-N hydrochloric acid. the crystals obtained were filtered off under suction, washed with water and recrystallized from 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine; melting point 217-220. In a manner analogous to that described in Example 1 6.27 g of <strong>[58-71-9]<strong>[58-71-9]cephalothin sodium</strong> salt</strong> were reacted 3.04 g of 1-ethyl-5-chloro-1,2-dihydro-4-mercapto-2-oxo-pyrimidine prepared above to give (7R)-3-[[(1-ethyl-5-chloro-1,2-dihydro-2-oxo-4-pyrimidinyl)-thio]methyl]-7-[2-(2-thienyl)-acetamido]-3-cephem-4-carboxylic acid as the sodium salt; yield 3.5 g (42%); melting point from 185 (decomposition); [alpha]D20 = -95.2 (c = 0.394 in water).

Reference： [1]Patent: US4091211,1978,A

22
cis-diaminediiodoplatinum(II) [ No CAS ]
[ 6490-42-2 ]
cis-[Pt(1-ethyluracilate)2(NH₃)2] [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1997,vol. 263,p. 69 - 79

23
[ 6490-42-2 ]
cis-[Pt₂(1-ethyluracilate)2(NH₃)4](NO₃)2 [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1997,vol. 263,p. 69 - 79

24
[ 75-03-6 ]
[ 66-22-8 ]
[ 6490-42-2 ]
[ 5148-09-4 ]
[ 22390-04-1 ]
[ 25902-95-8 ]

Reference： [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 354 - 362

25
[ 66-22-8 ]
ethyl halide [ No CAS ]
[ 6490-42-2 ]
[ 22390-04-1 ]

Reference： [1]European Journal of Organic Chemistry,2019,vol. 2019,p. 2759 - 2766

26
[ 64-17-5 ]
[ 66-22-8 ]
[ 6490-42-2 ]

Yield	Reaction Conditions	Operation in experiment
53%		General procedure: To a double-necked round bottom flask (100mL), equipped with a condenser, it was added a mixture of KI (1.5mmol), P2O5 (1.5mmol) and the desired alcohol (1mmol) in DMF (5mL). The reaction mixture was stirred at r.t. for 30min. Next, the considered nucleobase (1mmol), K2CO3 (1mmol) and Et3N (1mmol) were added and the reaction mixture was heated to reflux for a further 6.5-10.5h (until TLC indicated no further progress in reaction, Table5). The solvent was then evaporated at reduced pressure, and the remaining foam was dissolved in chloroform (150mL) and washed with water (2×150mL). The organic layer was dried on Na2SO4 (1g) and evaporated. The product was purified using short column chromatography on silica gel eluting with proper solvents.

Reference： [1]Tetrahedron,2019,vol. 75

27
[ 74-96-4 ]
[ 10457-14-4 ]
[ 6490-42-2 ]