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Chemical Structure| 64513-70-8 Chemical Structure| 64513-70-8

Structure of 64513-70-8

Chemical Structure| 64513-70-8

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Product Details of [ 64513-70-8 ]

CAS No. :64513-70-8
Formula : C6H9NO3
M.W : 143.14
SMILES Code : O=C(O)CNC(C1CC1)=O
MDL No. :MFCD01724840
InChI Key :NDLLIOPAEOBFKZ-UHFFFAOYSA-N
Pubchem ID :47410

Safety of [ 64513-70-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 64513-70-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64513-70-8 ]

[ 64513-70-8 ] Synthesis Path-Downstream   1~6

  • 3
  • [ 4023-34-1 ]
  • [ 56-40-6 ]
  • [ 64513-70-8 ]
YieldReaction ConditionsOperation in experiment
To a mixture of 8.5 g of sodium carbonate, 3.2 g of sodium hydroxide, 100 ml of water, 100 ml of THF and 5.0 g of glycine was added 7.7 g of cyclopropanecarbonyl chloride at 0C, then, the mixture was stirred at room temperature for 15 hours. Concentrated hydrochloric acid was added until pH of the mixture reached 2, and THF was distilled off under reduced pressure. To the residue was added 400 ml of ethyl acetate, and the mixture was stirred at room temperature for 3 hours.The mixture was filtrated, and 50 ml of water was added to the filtrate, and this was extracted three times with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated under reduced pressure to obtain 9.6 g of ( cyclopropanecarbonyl- amide ) -acetic acid.1 H-NMR (D SO-D6) delta: 12.49 (1H, s), 8.40-8.35 (1H, m) , 3.76 (2H, d) , 1.66-1.59 (1H, m) , 0.66 (4H, d) .
  • 4
  • [ 64513-70-8 ]
  • [ 853078-13-4 ]
  • 5
  • [ 64513-70-8 ]
  • [ 557090-55-8 ]
  • [ 1447960-88-4 ]
  • 6
  • [ 641615-34-1 ]
  • [ 64513-70-8 ]
  • N-[2-oxo-6-(5-pyrimidyl)pyran-3-yl]cyclopropanecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
8% With acetic anhydride; at 90℃; for 6h; acetic anhydride (2.70 mL, 28.56 mmol) was added to a mixture of 1-(5-pyrimidyl)-3-(dimethylamino)-2-propene-1-one (385 mg, 2.20 mmol) and <strong>[64513-70-8]2-(cyclopropanecarboxamido)acetic acid</strong> (314 mg, 2.20) and the mixture was heated at 90 C. for 6 hours, after which time TLC showed complete consumption of the starting material. The volatiles were removed in vacuo before the crude material was purified by flash chromatography on silica gel (solvent EtOAc) to afford the title compound as a yellow solid (47 mg, 8%). 1H NMR deltaH (DMSO-d6, 300 MHz): 10.12 (br, 1H), 9.32 (s, 1H), 9.20 (s, 2H), 8.26 (d, J=8.0 Hz, 1H), 7.33 (d, J=8.0 Hz, 1H), 2.31 (br, 1H), 0.84-0.82 (m, 4H) ppm. ESI-MS 258.0 [MH]+.
 

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