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Chemical Structure| 64210-67-9 Chemical Structure| 64210-67-9
Chemical Structure| 64210-67-9

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Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate

CAS No.: 64210-67-9

4.5 *For Research Use Only !

Cat. No.: A440216 Purity: 98%

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Product Details of [ 64210-67-9 ]

CAS No. :64210-67-9
Formula : C9H10N2O3
M.W : 194.19
SMILES Code : O=C(OCC)CC(C1=NC=NC=C1)=O
MDL No. :MFCD16988278

Safety of [ 64210-67-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 64210-67-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 64210-67-9 ]

[ 64210-67-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 64210-67-9 ]
  • [ 26893-39-0 ]
  • 2-pyrimidin-4-yl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.15g (56%) With potassium carbonate; In methanol; water; 1.1 2-Pyrimidin-4-yl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one A mixture of 1.75g (9.0 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, (prepared according to the method described in patent DE 2705582), 5.0g (30.55 mmol) <strong>[26893-39-0]1,4,5,6-tetrahydro-2-pyrimidinamine dihydrochloride</strong> (prepared according to US Patent No. 4,262,122) and 2.49g (18.0 mmol) of potassium carbonate in 30ml of methanol were heated at reflux temperature during 18 h. The reaction mixture was cooled and the solvent removed by evaporation. The residue obtained was treated with water and the precipitate recovered by filtration to give 1.15g (56%) of product. Mp.: 268-272C.
  • 2
  • [ 64210-67-9 ]
  • [ 1450-93-7 ]
  • [ 589755-01-1 ]
YieldReaction ConditionsOperation in experiment
With ammonium acetate; In water; acetonitrile; 1.1. 7-(pyrimidin-4-yl)-1 H-imidazo[1,2-a]pyrimidin-5-one A mixture containing 2.9g (15 mmol) of 3-oxo-3-(pyrimidin-4-yl)-propionic acid ethyl ester (prepared by analogy to the method described in patent DE 2705582), 2g (15 mmol) of <strong>[1450-93-7]2-aminoimidazole hemisulfate</strong> and 1.2g (15 mmol) of ammonium acetate was heated at 140OEC during 18 h. The cooled mixture was treated with 30ml of acetonitrile and filtered and the precipitate was added to water and heated at reflux temperature for 30 min. The resulting solution was cooled and the precipitate recovered by filtration. The crude product thus obtained was recrystallised from ethanol to give 1.75g of pure product as a gray solid. Mp: 345-346OEC
 

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