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Chemical Structure| 63190-44-3 Chemical Structure| 63190-44-3

Structure of 63190-44-3

Chemical Structure| 63190-44-3

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Product Details of [ 63190-44-3 ]

CAS No. :63190-44-3
Formula : C6H12ClNO
M.W : 149.62
SMILES Code : N=C(C1CC1)OCC.[H]Cl
MDL No. :MFCD11865278

Safety of [ 63190-44-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 63190-44-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63190-44-3 ]

[ 63190-44-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 63190-44-3 ]
  • [ 57297-29-7 ]
YieldReaction ConditionsOperation in experiment
With ammonia; In ethanol; at 20℃; Ethyl cyclopropanecarboximidate monohydrochloride (40.5 g 0.27 mol) was added portionwise to a saturated solution of ammonia in ethanol (50 mL). A further portion of ethanol (33 mL) was added. The mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure, and the residue was dissolved in ethanol to give the title composition (83 mL).
  • 2
  • [ 456-14-4 ]
  • [ 63190-44-3 ]
  • [ 1038410-94-4 ]
  • 5-cyclopropyl-3-(4-fluorophenyl)-1H-1,2,4-triazole [ No CAS ]
  • 3
  • [ 38980-96-0 ]
  • [ 63190-44-3 ]
  • 3,5-di-(p-(trifluoromethyl)phenyl)-1H-1,2,4-triazole [ No CAS ]
  • 5-cyclopropyl-3-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
7%; 46% With iodine; caesium carbonate; In 1,2-dichloro-benzene; at 130℃; for 16h; General procedure: To a stirred solution of amidine hydrochloride 1 (1.0 mmol) and imidate hydrochloride 3 (2.0 mmol) in o-dichlorobenzene (4.0 mL) was added Cs2CO3 (1.3g, 4.0 mmol) followed by iodine (254 mg, 1.0 mmol) at room temperature. The reaction mixture was stirred at 130 C for 16 h. After cooling to room temperature the reaction mixture was diluted with 10% aqueous Na2S2O3 (4.0 mL) and the product was extracted with EtOAc (2 × 15 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and evaporated in vacuum. The crude product was purified by flash column chromatography over silica gel using EtOAc/n-Hexane as the eluent to afford the desired product 4.
 

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