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Chemical Structure| 6302-53-0 Chemical Structure| 6302-53-0

Structure of 6302-53-0

Chemical Structure| 6302-53-0

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Product Details of [ 6302-53-0 ]

CAS No. :6302-53-0
Formula : C8H9N3
M.W : 147.18
SMILES Code : C1(C2=NCCN2)=CC=CN=C1
MDL No. :MFCD00090296

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Application In Synthesis of [ 6302-53-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6302-53-0 ]

[ 6302-53-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6302-53-0 ]
  • [ 42260-39-9 ]
  • [ 1375748-16-5 ]
YieldReaction ConditionsOperation in experiment
76% With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100℃;Inert atmosphere; General procedure (0.5-3.0 mmol scale) for the preparation of compounds 2a-t: A thick-glass, screw-capped pressure tube (50 mL) was charged with a suspension of the starting imidazoline (1.0 equiv), heteroaryl halide (1.1 equiv) and Cs2CO3 (1.0-3.0 equiv, an additional equivalent per salt component of the reactants) in toluene (3 mL/mmol). Pd(OAc)2 (0.02 equiv) and BINAP (0.4 equiv) were weighed out into a vial, suspended in toluene (2 mL/mmol) and shaken in a 100 °C oil bath for 2 min. The resulting clear, purple catalyst solution was added in one portion to the vigorously stirred reaction mixture. The tube was filled with argon, capped, and stirred at 100 °C for 16-20 h. The mixture was cooled, and partitioned between EtOAc and H2O. The organic layer was separated, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The resulting crude material was purified by column chromatography on silica gel using an appropriate gradient of acetone in hexane (or MeOH in CH2Cl2) as eluent to provide the target product 2.
 

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