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Chemical Structure| 6291-10-7 Chemical Structure| 6291-10-7

Structure of 6291-10-7

Chemical Structure| 6291-10-7

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Product Details of [ 6291-10-7 ]

CAS No. :6291-10-7
Formula : C8H8ClNO3
M.W : 201.61
SMILES Code : O=C(O)C1=CC(OCC)=NC(Cl)=C1
MDL No. :MFCD11214832

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Application In Synthesis of [ 6291-10-7 ]

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  • Downstream synthetic route of [ 6291-10-7 ]

[ 6291-10-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 850568-54-6 ]
  • [ 6291-10-7 ]
  • [ 1370448-69-3 ]
YieldReaction ConditionsOperation in experiment
20% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In dimethoxyethane-1,2; water; at 90℃; The crude 2-chloro-6-ethoxyisonicotinic acid (0.5 g, ca. 2.6 mmol), 4-(tert- butoxycarbonyl) benzene boronic acid (0.5g, 2.2 mmol), potassium carbonate (0.5g, 3.6 mmol) and water (0.1 ml_) in 1 ,2-dimethoxyethane (10 ml_) were stirred and degassed for 10 min. Tetrakis(triphenylphosphine)palladium (0.1 g, 0.08 mmol) was then added. The sealed tube was then heated over night at 90 °C. After cooling the reaction was passed through a plug a celite and partitioned betweendichloromethane and water. The organic solution was concentrated and the crude residue purified by chromatography (silica gel, 10percent methanol in dichloromethane) to afford the title compound (97 mg, 20percent). 1 H NMR (400 MHz, CDCI3) delta ppm 8.1 1 (2H, d), 8.08 (2H, d), 7.96 (1 H, s), 7.34 (1 H, s), 4.54 (2H, qd), 1 .61 (9H, s), 1 .46 (3H, t); m/z: 344+ [M+H].
 

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