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Chemical Structure| 6278-73-5 Chemical Structure| 6278-73-5

Structure of 6278-73-5

Chemical Structure| 6278-73-5

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Product Details of [ 6278-73-5 ]

CAS No. :6278-73-5
Formula : C13H10N2S
M.W : 226.30
SMILES Code : NC1=CC=C(C2=NC3=CC=CC=C3S2)C=C1
MDL No. :MFCD00182896
InChI Key :WKRCOZSCENDENK-UHFFFAOYSA-N
Pubchem ID :234475

Safety of [ 6278-73-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Application In Synthesis of [ 6278-73-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6278-73-5 ]

[ 6278-73-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 95-16-9 ]
  • [ 131818-17-2 ]
  • [ 6278-73-5 ]
  • (4-benzothiazol-2-yl-phenyl)-carbamic acid <i>tert</i>-butyl ester [ No CAS ]
  • 2
  • [ 6278-73-5 ]
  • [ 57774-35-3 ]
  • C39H24N4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
41.2% With tri-tert-butyl phosphine; Palladium(0) bis(dibenzylideneacetone); sodium tertiary butoxide; In 5,5-dimethyl-1,3-cyclohexadiene; at 130℃; for 1.2h; In a 1-neck 250 mL flask, 2.0 g (8.8 mmol) of 4-(benzo[d]thiazol-2-yl)aniline,<strong>[57774-35-3]4'-bromo-[1,1'-biphenyl]-4-carbonitrile</strong> (<strong>[57774-35-3]4'-bromo-[1,1'-biphenyl]-4-carbonitrile</strong>) 4.8 g (18.5 mmol), Pd (dba) 2 0.5 g (0.9 mmol), P(tBu) 30.8 mL (1.8 mmol),After mixing 2.5 g (26.5 mmol) of NaOtBu and 35 mL of xylene, the mixture was heated to 130 C and stirred for 1 hour and 20 minutes. After completion of the reaction and cooling to room temperature, hexane was added and stirred for 30 minutes. The precipitated solid compound was filtered, washed with hexane, and filtered through Celite. After purification by silica gel column chromatography (HEX:DCM) and washing with acetone, 2.1 g (yield: 41.2%) of a pale yellow solid compound 2-182 (LT20-30-063) was obtained.
 

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