Home Cart Sign in  
Chemical Structure| 6269-89-2 Chemical Structure| 6269-89-2

Structure of 6269-89-2

Chemical Structure| 6269-89-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 6269-89-2 ]

CAS No. :6269-89-2
Formula : C10H13N3O2
M.W : 207.23
SMILES Code : C1=CC(=CC=C1N2CCNCC2)[N+](=O)[O-]
MDL No. :MFCD00005961
InChI Key :VWOJSRICSKDKAW-UHFFFAOYSA-N
Pubchem ID :80447

Safety of [ 6269-89-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332-H315-H319-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 6269-89-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6269-89-2 ]

[ 6269-89-2 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 6269-89-2 ]
  • [ 182438-98-8 ]
  • [ 331767-31-8 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 17 9-{4-[4-(4-nitro-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide Prepared analogously to Example 2 b from 1-(4-nitro-phenyl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide. Yield: 0.35 g (38.6% of theoretical). Melting point: 146 C. C30H31F3N4O3 (M=552.60).
  • 2
  • [ 401564-36-1 ]
  • [ 6269-89-2 ]
  • [ 401566-15-2 ]
  • 3
  • [ 3471-31-6 ]
  • [ 6269-89-2 ]
  • [ 214124-59-1 ]
  • 4
  • [ 6269-89-2 ]
  • [ 74-88-4 ]
  • [ 16155-03-6 ]
YieldReaction ConditionsOperation in experiment
1.0 g (90%) In N-methyl-acetamide; Step 1 1.04 g (5.0 mmol) of N-(4-nitrophenyl)piperazine was dissolved in 5 ml of dimethylformamide. Sodium hydride (0.24 g, 6.0 mmol) was added to the reaction mixture in three portions under nitrogen atmosphere and cooling over a period of 10 min. After 30 min of stirring, 0.31 ml (6.0 mmol) of methyl iodide was added dropwise to the reaction mixture at 0 C. Stirring was continued for 1 h at room temperature, the reaction mixture was then evaporated to dryness, and purified by silica gel chromatography (methylene chloride:methanol:triethylamine 94:5:1) to yield 1.0 g (90%) of 1-methyl-4-(4-nitrophenyl)piperazine.
  • 5
  • [ 3471-31-6 ]
  • [ 6269-89-2 ]
  • [ 530-62-1 ]
  • [ 214124-59-1 ]
YieldReaction ConditionsOperation in experiment
91% In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 14.1 1-[(5-methoxy-1H-indol-3-yl)methylcarbonyl]-4-(4-nitrophenyl)-piperazine In a 100 ml flask, 1.62 g (10 mmoles) of 1.1'-carbonyl-diimidazole is added to a solution of 2.05 g (10 mmoles) of 5-methoxyindole-3-acetic acid in 10 ml of THF. After one hour of agitation at ambient temperature, a solution of 1-(4-nitrophenyl)piperazine in 10 ml of DMF is added dropwise. Agitation is continued for 15 hours. The reaction medium is then concentrated under vacuum and the evaporation residue is precipitated from 50 ml of an ethyl acetate/water mixture (1/1). After filtration, the solid is rinsed successively with 50 ml of water, 50 ml of ethyl acetate and 50 ml of dichloromethane. After drying under vacuum, a yellow powder is obtained with a yield of 91percent. Melting point: 239-240° C. NMR 1H (100 MHz, DMSO d6, delta): 10.90 (m, 1H, NH); 7.63 (m, 4H, Ph-NO2); 7.40-7.15 (m, 3H, indol); 6.87 (dd, 1H indol, Jotho=8.7 Hz, Jmeta=2.8 Hz); 3.90 (s, 2H, CH2-CO); 3.88 (s, 3H, OCH3); 3.79 (m, 4H, piperazine); 3.50 (m, 4H, piperazine).
91% 14.1) 1-[(5-methoxy-1H-indol-3-yl)methylcarbonyl]-4-(4-nitrophenyl)piperazine: In a 100 ml flask, 1.62 g (10 mmoles) of 1.1'-carbonyl-diimidazole is added to a solution of 2.05 g (10 mmoles) of 5-methoxyindole-3-acetic acid in 10 ml of THF. After one hour of agitation at ambient temperature, a solution of 1-(4-nitrophenyl)piperazine in 10 ml of DMF is added dropwise. Agitation is continued for 15 hours. The reaction medium is then concentrated under vacuum and the evaporation residue is precipitated from 50 ml of an ethyl acetate/water mixture (1/1). After filtration, the solid is rinsed successively with 50 ml of water, 50 ml of ethyl acetate and 50 ml of dichloromethane. After drying under vacuum, a yellow powder is obtained with a yield of 91percent. Melting point: 239-240° C. NMR 1H (100 MHz, DMSO d6, delta): 10.90 (m, 1H, NH); 7.63 (m, 4H, Ph-NO2); 7.40-7.15 (m, 3H, indol); 6.87 (dd, 1H indol, Jortho=8.7 Hz, Jmeta=2.8 Hz); 3.90 (s, 2H, CH2-CO); 3.88 (s, 3H, OCH3); 3.79 (m, 4H, piperazine); 3.50 (m, 4H, piperazine).
  • 6
  • [ 6269-89-2 ]
  • [ 287730-14-7 ]
  • [ 1352002-40-4 ]
  • 7
  • [ 646-06-0 ]
  • [ 6269-89-2 ]
  • [ 2923-66-2 ]
  • 1-(3-chloro-4-fluorophenyl)-3-(4-(4-nitrophenyl)piperazin-1-yl)propan-1-one [ No CAS ]
  • 8
  • [ 463-57-0 ]
  • [ 6269-89-2 ]
  • [ 16155-03-6 ]
YieldReaction ConditionsOperation in experiment
94% With sodium acetate; acetic acid; at 100℃; for 24h;Sealed tube; 1.0 g of 1-(4-nitrophenyl)-piperazine (Compound A-1f), 12 mL of acetic acid was added to the sealed reactor, followed by the addition of 2.5 mL of hydrated formaldehyde, 1.0 g of sodium acetate;The reaction mixture was warmed to 100 C and stirred for 24 hours;The residue obtained was purified to give 1-(4-nitrophenyl)-4-methylpiperazine (A-f) (1.0 g, yield 94%).
  • 9
  • [ 6269-89-2 ]
  • [ 94088-46-7 ]
  • 2‑methoxy‑6‑[4‑(4‑nitrophenyl)piperazin‑1‑yl]benzonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With tetrabutylammomium bromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In water; for 3h;Reflux; In a round bottom flask, 5 cm3 water,0.453 g of <strong>[94088-46-7]2-fluoro-6-methoxybenzonitrile</strong> (0.003 mol), 0.621 g of 1-(4-nitrophenyl)piperazine (0.003 mol), 0.387 gof DIPEA (0.003 mol), 0.096 g of TBAB (0.0003 mol), and 0.318 g of Na2CO3(0.003 mol) was taken. Reaction was carried out at reflux for 3 h. Then reaction mixture was cooled and extracted with ethyl acetate. The product was purified by flash chromatography on silica using hexane-ethyl acetate mobile phase to afford 0.42 g 16 (42%). M.p.:160-164 C; 1H NMR (400 MHz, CDCl3):delta = 3.939 (s, 4H),3.649 (s, 4H), 3.953 (s, 3H), 6.630 (d, J = 4 Hz, 2H), 6.893(d, J = 8 Hz, 2H), 7.460 (t, J = 8 Hz, 1H), 8.165 (d, J = 8 Hz,2H) ppm; 13C NMR (100 MHz, CDCl3):delta = 46.1 (CH2), 46.8(CH2), 47.2 (CH2), 50.9 (CH2), 56.1 (OCH3), 104.8 (CCN),110.5 (CH), 112.9 (CH), 115.7 (CN), 129.9 (CH), 134.4(CH), 138.8 (CNO2), 154.7 (C), 156.6 (C), 163.0 (CO) ppm; IR (KBr): =nu 2886, 2215, 1594, 1480, 1322, 1600, 1508,1458, 1266 cm-1; ESI-MS: m/z = 339 (MH+).
 

Historical Records

Technical Information

Categories