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Chemical Structure| 62482-45-5 Chemical Structure| 62482-45-5

Structure of 62482-45-5

Chemical Structure| 62482-45-5

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Product Details of [ 62482-45-5 ]

CAS No. :62482-45-5
Formula : C14H11ClO
M.W : 230.69
SMILES Code : ClC1=CC(C(CC2=CC=CC=C2)=O)=CC=C1
MDL No. :MFCD02260665

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Application In Synthesis of [ 62482-45-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62482-45-5 ]

[ 62482-45-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 62482-45-5 ]
  • [ 57-13-6 ]
  • [ 1283117-46-3 ]
YieldReaction ConditionsOperation in experiment
8.6% With hydrogenchloride; In ethanol; water;Reflux; [00182] A mixture of l-(3-chlorophenyl)-2-phenylethanone (450 mg, 1.95 mmol), 3- ethoxy-4-hydroxy-5-nitrobenzaldehyde (411 mg, 1.95 mmol), and urea (350 mg, 5.83 mmol) in anhydrous EtOH (15 mL) was added concentrated HC1 solution (0.5 mL), the reaction mixture was refluxed overnight. TLC (EtOAc:MeOH=10: l) showed that about 30% of starting materials were consumed, and the reaction mixture was concentrated. The residue was purified by column chromatography (EtOAc:MeOH=40: l) and preparative HPLC to afford Compound 37 as a yellow solid (78.1 mg, yield: 8.6%). 1H NMR (DMSO- 6 400 MHz): delta 10.30 (s, 1H), 8.81 (s, 1H), 7.56 (s, 1H), 7.42 (d, J = 1.2 Hz, 1H), 7.30 (d, J = 8.0 Hz, 1H), 7.20-7.25 (m, 2H), 7.02-7.7.13 (m, 5H), 6.85 (d, J = 6.8 Hz, 2H), 5.25 (d, J = 2.8 Hz, 1H), 4.00-4.10 (m, 2H), 1.33 (t, J = 6.8 Hz, 3H); MS (ESI): m/z 466.0 [M+l]+.
 

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