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Chemical Structure| 623155-66-8 Chemical Structure| 623155-66-8

Structure of 623155-66-8

Chemical Structure| 623155-66-8

3-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride

CAS No.: 623155-66-8

4.5 *For Research Use Only !

Cat. No.: A497285 Purity: 95+%

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Product Details of [ 623155-66-8 ]

CAS No. :623155-66-8
Formula : C11H15ClN2O
M.W : 226.70
SMILES Code : O=C(C1C=C(N)C(C)=CC=1)NC1CC1.[H]Cl
MDL No. :N/A

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Application In Synthesis of [ 623155-66-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 623155-66-8 ]

[ 623155-66-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 623155-66-8 ]
  • [ 4576-90-3 ]
  • [ 1026765-94-5 ]
YieldReaction ConditionsOperation in experiment
91% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 50℃; for 1h; [00163] To a solution of <strong>[4576-90-3]isothiazole-3-carboxylic acid</strong> (20 mg, 0.15 mmol), EDC (32.4 mg, 0.17 mmol), HOBt (23. mg, 0.17 mmol) in DMF (0.3 mL) was added 3- amino-N-cyclopropyl-4-methyl-benzamide hydrochloride (35 mg, 0.15 mmol) followed by DIPEA (0.03 mL, 0.17 mmol). The reaction was heated at 500C for 1 h. Water (0.6 mL) was added dropwise and the reaction removed from heating. The solids were stirred overnight at room temp, filtered, and washed with water to give (42.1 mg, 91% yield). HPLC tR= 2.63 min, 99.80 % purity; LCMS 302.1 (M + H).
 

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