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Chemical Structure| 62009-33-0 Chemical Structure| 62009-33-0

Structure of 62009-33-0

Chemical Structure| 62009-33-0

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Product Details of [ 62009-33-0 ]

CAS No. :62009-33-0
Formula : C5H5BrN2O2S
M.W : 237.07
SMILES Code : NS(=O)(=O)C1=CC(Br)=CN=C1
MDL No. :MFCD08235088

Safety of [ 62009-33-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 62009-33-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 62009-33-0 ]

[ 62009-33-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 62009-33-0 ]
  • [ 73183-34-3 ]
  • [ 1083326-26-4 ]
YieldReaction ConditionsOperation in experiment
100% With potassium acetate In 1,4-dioxane at 120℃; for 0.666667 h; microwave irradiation A mixture of 5-bromo-3-pyridinesulfonamide (6.33 mmol), bis(pinacolato)diboron (6.96 mmol), potassium acetate (18.99 mmol), and dichloro[l,r-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (0.32 mmol) in 1,4-dioxane (15 mL) was irradiated in the microwave at 120 0C for 40 min. The reaction was filtered through Celite, washed with dioxane, and the filtrate was concentrated in vacuo to provide the title compound as a brown solid (quantitative). MS(ES)+ m/e 203 [M+H]+ for acid. Alternatively, the residue can be purified by trituration in dichloromethane to give a light brown solid. IH NMR (400 MHz, DMSO-J6) δ ppm 8.76 (s, 2 H), 8.22 (s, 1 H), 7.45 (br s, 2 H), 1.13 (s, 12 H).
References: [1] Patent: WO2008/150827, 2008, A1, . Location in patent: Page/Page column 59.
[2] Patent: WO2011/28741, 2011, A1, . Location in patent: Page/Page column 215.
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4613 - 4618.
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 9, p. 3795 - 3803.
 

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