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Chemical Structure| 620-94-0 Chemical Structure| 620-94-0

Structure of 620-94-0

Chemical Structure| 620-94-0

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Product Details of [ 620-94-0 ]

CAS No. :620-94-0
Formula : C14H14S
M.W : 214.33
SMILES Code : CC1=CC=C(SC2=CC=C(C)C=C2)C=C1
MDL No. :MFCD00459698

Safety of [ 620-94-0 ]

Application In Synthesis of [ 620-94-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 620-94-0 ]

[ 620-94-0 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 620-94-0 ]
  • [ 599-66-6 ]
YieldReaction ConditionsOperation in experiment
98% With Octanoic acid; dihydrogen peroxide; In acetonitrile; at 50℃; for 0.5h;Schlenk technique; Green chemistry; General procedure: An oven-dried Schlenk flask was allowed to cool toroom temperature and charged sequentially with sulfide(1.0 mmol), MeCN (3.0 mL) and caprylic acid (20 mol%).The reaction was then activated by the addition of 30%H2O2 (2.4 equiv.) and stirred at 50 C for the required timeas given in Table 4. The progress of reaction was monitoredby GC. After completion of the reaction, the reaction was quenched by adding aqueous solution of 10% Na2SO3to the reaction mixture. Then the product was extractedwith CH2Cl2 (30 mL) and then washed with distilled water(10 mL). The organic extract dried over Na2SO4 and thesolvent removed under reduced pressure. The resultantproduct was purified (if necessary) by column chromatographyusing silica gel (60-120 mesh) with n-hexaneand ethyl acetate as solvent to get the pure product. Thestructure of the product was confirmed by GC-MS, M.P./B.P. and 1H NMR spectroscopic techniques.
  • 3
  • [ 1774-35-2 ]
  • [ 620-94-0 ]
  • [ 599-66-6 ]
YieldReaction ConditionsOperation in experiment
83%; 12% With [ReOCl3(PPh3)2]; In chloroform; for 17h;Reflux; General procedure: To a solution of ReOCl3(PPh3)2 (10.0 mol %) in CHCl3 (3 mL) was added the sulfoxide (1.0 mmol). The reaction mixture was heated at reflux temperature under air atmosphere (the reaction times are indicated in the Table 1, Table 2 and Table 3) and the progress of the reaction was monitored by TLC or 1H NMR. Upon completion, the reaction mixture was evaporated and purified by silica gel column chromatography with n-hexane to afford sulfides and sulfones, which are all known compounds.
  • 4
  • [ 599-66-6 ]
  • [ 620-94-0 ]
  • 5
  • [ 29110-75-6 ]
  • [ 4630-20-0 ]
  • [ 613-33-2 ]
  • [ 620-94-0 ]
  • [ 599-66-6 ]
  • 6
  • [ 2935-90-2 ]
  • [ 824-79-3 ]
  • [ 15441-06-2 ]
  • [ 620-94-0 ]
  • [ 108-88-3 ]
  • 3-(4-methylphenylsulfanyl)propionic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
37%Chromat. With silver nitrate; palladium dichloride; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 120℃; for 0.166667h;Microwave irradiation; General procedure: Aryl sulfinate metal salt (0.36 mmol or 0.18 mmol), PdCl2 (0.06 mmol), AgNO3(0.6 mmol), DMF/DMSO (v/v = 19/1, 2 mL), and thiol (0.3 mmol) were added to the microwave tube. The tube was sealed and stirred for 5 min at ambient temperature. The tube was then heated at 40W for 10 min at 120 °C. After cooling down, the resulting suspensions were filtered off and washed with CH2Cl2. A small amount of silica gel was added into the filtrate, and then evaporated. The residue was purified by flash chromatography on silica with hexane/EA to provide the desired product.
  • 7
  • [ 2935-90-2 ]
  • [ 824-79-3 ]
  • [ 15441-06-2 ]
  • [ 620-94-0 ]
  • 3-(4-methylphenylsulfanyl)propionic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
76%Chromat. With silver carbonate; palladium dichloride; In tetrahydrofuran; at 120℃; for 0.166667h;Microwave irradiation; General procedure: Aryl sulfinate metal salt (0.36 mmol or 0.18 mmol), PdCl2 (0.06 mmol), AgNO3(0.6 mmol), DMF/DMSO (v/v = 19/1, 2 mL), and thiol (0.3 mmol) were added to the microwave tube. The tube was sealed and stirred for 5 min at ambient temperature. The tube was then heated at 40W for 10 min at 120 °C. After cooling down, the resulting suspensions were filtered off and washed with CH2Cl2. A small amount of silica gel was added into the filtrate, and then evaporated. The residue was purified by flash chromatography on silica with hexane/EA to provide the desired product.
 

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