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Chemical Structure| 618-47-3 Chemical Structure| 618-47-3

Structure of 618-47-3

Chemical Structure| 618-47-3

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Product Details of [ 618-47-3 ]

CAS No. :618-47-3
Formula : C8H9NO
M.W : 135.16
SMILES Code : O=C(N)C1=CC=CC(C)=C1
MDL No. :MFCD00007990
InChI Key :WGRPQCFFBRDZFV-UHFFFAOYSA-N
Pubchem ID :69253

Safety of [ 618-47-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 618-47-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 618-47-3 ]

[ 618-47-3 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 618-47-3 ]
  • [ 4481-28-1 ]
  • 2
  • [ 134-62-3 ]
  • [ 618-47-3 ]
  • 3
  • [ 618-47-3 ]
  • [ 2362-63-2 ]
YieldReaction ConditionsOperation in experiment
With Lawessons reagent; In tetrahydrofuran; for 4h;Reflux; General procedure: To a solution of benzamide 11a-u (1 equiv) in THF (30mL) was added Lawesson’s reagent (0.6 equiv), and the mixture was heated to reflux for 4 hrs. The reaction mixture was concentrated invacuo,then diluted with ethyl acetate (30 ml), and washed with 1N NaHCO3 (3× 20 mL) and brine (2 × 20 mL). The organic layer was dried over anhydrous sodium sulfate,filtered and evaporated under reduced pressure. The crude product was purified by silica gel column chromatography using a mixture of dichloromethane/methanol(100:1, v/v) as eluent to afford a yellow solid product.A solution of the obtained solid 12a-u (1 equiv) and ethyl 2-chloroacetoacetate (1.2 equiv) in ethanol (25 ml) was heated to reflux for 6 h, then the mixture was allowed to stand at 0 C for 10 hrs, and a white needle crystal was precipitate out.The reaction mixture was filtered and the filter cake was washed with 10 mL of ethanol, dried in vacuum to give the desired product.
  • 4
  • [ 51012-64-7 ]
  • [ 618-47-3 ]
 

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