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Chemical Structure| 61394-50-1 Chemical Structure| 61394-50-1

Structure of 5-Cyanooxindole
CAS No.: 61394-50-1

Chemical Structure| 61394-50-1

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Product Details of [ 61394-50-1 ]

CAS No. :61394-50-1
Formula : C9H6N2O
M.W : 158.16
SMILES Code : N#CC1=CC2=C(NC(C2)=O)C=C1
MDL No. :MFCD02179599
InChI Key :NZOSLRYUVHMXTQ-UHFFFAOYSA-N
Pubchem ID :2773346

Safety of [ 61394-50-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H317-H319-H335
Precautionary Statements:P260-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 61394-50-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61394-50-1 ]

[ 61394-50-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124467-36-3 ]
  • [ 61394-50-1 ]
  • 2-Hydroxy-3-(5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indole-5-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With sodium hexamethyldisilazane; In tetrahydrofuran; at 110℃; for 0.166667h;Microwave irradiation; 3.3 2-Hydroxy-3-(5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indole-5-carbonitrileTo a suspension of <strong>[124467-36-3]2-chloro-7,8-dihydroquinolin-5(6H)-one</strong> (50 mg, 0.275 mmol) and 2-oxoindoline-5-carbonitrile (45.7 mg, 0.289 mmol) in tetrahydrofuran (1.4 mL) was added a 1.0 M solution of sodium bis(trimethylsilyl)amide (641 muL, 0.641 mmol). The mixture was stirred for 3 min at RT and then heated in a microwave oven to 110 C. for 10 min. After cooling to RT the reaction was quenched by addition of methanol (1 mL). The resulting solution was evaporated to dryness. The crude was purified by flash chromatography (silica gel, dichloromethane/methanol) yielding an orange solid. Amount 17 mg. Yield 20%.1H-NMR (DMSO-d6, 400 MHz) delta 2.17 (m, 2H), 2.59 (t, 2H), 3.08 (t, 2H), 7.06 (d, 1H), 7.38 (dd, 1H), 7.68 (d, 1H), 7.98 (m, 2H), 11.11 (s, 1H), 14.78 (bs, 1H)MS (ES-API) m/z 304 (M+H+, 100%).
 

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