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Chemical Structure| 60330-35-0 Chemical Structure| 60330-35-0

Structure of 60330-35-0

Chemical Structure| 60330-35-0

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Product Details of [ 60330-35-0 ]

CAS No. :60330-35-0
Formula : C8H6F3N3
M.W : 201.15
SMILES Code : NC1=NNC2=C1C=CC=C2C(F)(F)F
MDL No. :MFCD03426698

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Application In Synthesis of [ 60330-35-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 60330-35-0 ]

[ 60330-35-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1260088-72-9 ]
  • [ 60330-35-0 ]
  • C19H16F3N7O [ No CAS ]
  • 2
  • [ 1260088-72-9 ]
  • [ 60330-35-0 ]
  • C16H13ClF3N5O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;Heating; General procedure: A mixture of <strong>[1260088-72-9]2,4-dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine</strong>7 (257mg, 1.173 mmol), 1H-pyrazolo[4,3-c]pyridin-3-amine (291 mg, 1.735 mmol), N,N-diisopropylethylamine (0.40 mL, 2.3 mmol) and N,N-dimethylformamide (4.0 mL) was heated at 70 C for 2 hours. The reaction mixture was diluted with ethyl acetate, washed with water (2x) and brine, dried over magnesium sulfate, filtered, and evaporated in vacuo. The crude product was purified via flash chromatography on silica gel (24 silica, solvent gradient: 0-100% ethyl acetate in dichloromethane followed by 10% methanol indichloromethane) to yield 176.7 mg of the title compound.
 

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