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Chemical Structure| 603143-27-7 Chemical Structure| 603143-27-7

Structure of 603143-27-7

Chemical Structure| 603143-27-7

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Product Details of [ 603143-27-7 ]

CAS No. :603143-27-7
Formula : C13H19BO4S
M.W : 282.16
SMILES Code : CC1(C)OB(OC1(C)C)C1=CC=C(C=C1)S(C)(=O)=O
MDL No. :MFCD05863921
Boiling Point : No data available
InChI Key :BDOSWBBKOSGKAV-UHFFFAOYSA-N
Pubchem ID :2759530

Safety of [ 603143-27-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 603143-27-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 603143-27-7 ]

[ 603143-27-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 603143-27-7 ]
  • [ 21543-49-7 ]
  • (6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,4-dioxane; water; at 100℃;Inert atmosphere; To a stirred solution of (6-chloropyridin-3-yl)methanol (0.32 g, 2.6 mmol) and 4,4,5,5-tetramethyl-2- (4-(methylsulfonyl)phenyl)-1 ,3,2-dioxaborolane (0.66 g, 2.7 mmol) in dry dioxane (2 ml_), a solution of cesium carbonate (1 .3 g, 4.3 mmol) in water (1 mL) was added at RT. The reaction mixture was purged with nitrogen for 10 min. Tetrakis(triphenylphosphine)pailadium(0) (0.04 g, 0.4 mmol) was then added at RT and the reaction mixture was heated overnight at 100 C. The reaction mixture was filtered through celite pad and the filtrate was concentrated under vacuum. The resulting crude product was purified by flash chromatography (Eluent: 70% EtOAc in pet ether) to afford the title compound. Yield: 69.0% (200 mg, off white solid). 1H NMR (400 MHz, DMSO-d6): d 8.68 (s, 1 H), 8.37-8.34 (m, 2H), 8.10-8.02 (m, 3H), 7.90-7.88 (m, 1 H), 4.61 (d, J = 5.6 Hz, 2H), 3.27 (s, 3H). (0432) LCMS: (Method A) 264.2 (M+H), 1.17 min, 93.8% (Max).
 

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[ 603143-27-7 ]

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