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Chemical Structure| 1078-19-9 Chemical Structure| 1078-19-9
Chemical Structure| 1078-19-9

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Product Details of 6-Methoxy-1-tetralone

CAS No. :1078-19-9
Formula : C11H12O2
M.W : 176.21
SMILES Code : O=C1CCCC2=C1C=CC(OC)=C2
MDL No. :MFCD00001695
InChI Key :MNALUTYMBUBKNX-UHFFFAOYSA-N
Pubchem ID :14112

Safety of 6-Methoxy-1-tetralone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of 6-Methoxy-1-tetralone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1078-19-9 ]

[ 1078-19-9 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 1730-48-9 ]
  • [ 1885-13-8 ]
  • [ 1078-19-9 ]
  • 3
  • [ 105-36-2 ]
  • [ 1078-19-9 ]
  • [ 87901-81-3 ]
  • 4
  • [ 1078-19-9 ]
  • /PMAMJ162--930/ [ No CAS ]
  • [ 87901-81-3 ]
  • 5
  • [ 1078-19-9 ]
  • [ 51015-29-3 ]
  • 7
  • [ 80567-00-6 ]
  • [ 1078-19-9 ]
  • 6-methoxy-2-(2,6-dimethylmorpholinomethyl)-1,2,3,4-tetrahydronaphthalen-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
33% With paraformaldehyde;hydrogenchloride; In ethanol; EXAMPLE 1 This Example illustrates the preparation of 6-methoxy-2-(2,6-dimethylmorpholinomethyl)-1,2,3,4-tetrahydronaphthalene (compound No. 11 of Table 1). 6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one (17.6 g, 0.1 mol), <strong>[80567-00-6]2,6-dimethylmorpholine hydrochloride</strong> (15.1 g, 0.1 mol), and paraformaldehyde (6.0 g, 0.2 mol) were refluxed together in ethanol (50 ml) with concentrated hydrochloric acid (0.25 ml) as a catalyst for 3 hours. The reaction was cooled and poured into water containing concentrated hydrochloric acid (5 ml) and extracted with ether (200 ml). The aqueous solution was cooled in ice and neutralised with sodium hydroxide solution (10%) then extracted with ether (2*200 ml) dried over magnesium sulphate and evaporated under reduced pressure to give a residue which was recrystallized from petrol (60-80) to give 6-methoxy-2-(2,6-dimethylmorpholinomethyl)-1,2,3,4-tetrahydronaphthalen-1-one a white crystalline solid (10 g, 33% yield) melting at 110 C.
  • 8
  • [ 1078-19-9 ]
  • [ 703-67-3 ]
 

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