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Chemical Structure| 59227-89-3 Chemical Structure| 59227-89-3
Chemical Structure| 59227-89-3

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Laurocapram is a percutaneous enhancer, working by interacting with lipids in the stratum corneum. This may enhance the ability of the skin to absorb a hydrophilic chemical.

4.5 *For Research Use Only !

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Product Citations

Product Citations

Bednarczyk, Paulina ; Nowak, Anna ; Duchnik, Wiktoria ; Kucharski, Lukasz ; Ossowicz-Rupniewska, Paula ;

Abstract: This study investigated the impact of various enhancers on permeation through the skin and accumulation in the skin from acrylic pressure-sensitive adhesive-based drug-in-adhesives matrix-type transdermal patches. Eleven patches, each containing a 5% enhancer of permeation, encompassing compounds such as salicylic acid, menthol, urea, glycolic acid, allantoin, oleic acid, Tween 80, linolenic acid, camphor, N-dodecylcaprolactam, and glycerin, were developed. Ibuprofen (IBU) was the model active substance, a widely-used non-steroidal anti-inflammatory drug. The results were compared to patches without enhancers and commercial preparations. The study aimed to assess the effect of enhancers on IBU permeability. The adhesive properties of the patches were characterised, and active substance permeability was tested. The findings revealed that patches with 5% allantoin exhibited the highest IBU permeability, approximately 2.8 times greater than patches without enhancers after 24 h. These patches present a potential alternative to commercial preparations, highlighting the significant impact of enhancers on transdermal drug delivery efficiency.

Keywords: acrylic pressure-sensitive adhesives ; adhesion ; enhancers ; ibuprofen ; shear strength ; tack ; transdermal patch

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Product Details of Laurocapram

CAS No. :59227-89-3
Formula : C18H35NO
M.W : 281.48
SMILES Code : O=C1CCCCCN1CCCCCCCCCCCC
MDL No. :MFCD00190580
InChI Key :AXTGDCSMTYGJND-UHFFFAOYSA-N
Pubchem ID :42981

Safety of Laurocapram

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
 

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