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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 5913-13-3 Chemical Structure| 5913-13-3

Structure of 5913-13-3

Chemical Structure| 5913-13-3

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Product Citations

Product Citations

Moor, Sarah R. ; Howard, James R. ; Herrera, Brenden T. ; Anslyn, Eric V. ;

Abstract: A novel screening protocol was developed using a combination of a fluorescent indicator displacement assay and a CD (CD) active Fe(II) complex to determine concentration and enantiomeric excess (ee) of α-chiral amines, resp. The analyte concentration is quantified with a pre-formed non-fluorescent imine, where transmission with the chiral amine results in displacement of the fluorophore 2-naphthylamine. After discerning the concentration of amine via fluorescence in a well-plate reader, the analyte is then incorporated into a three-component octahedral Fe(II) assembly for ee determination using an EKKO CD plate-reader. With these two assays, both the ee and yield of asym. transformations of 192 samples could be determined with acceptable errors in under 15 min (not counting the preparation time). This combined speed and accuracy provides an attractive solution to overcoming anal. bottlenecks when creating α-chiral amines.

Keywords: Circular Dichroism ; Fluorescence ; High-throughput screening ; Indicator displacement assay

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Product Details of [ 5913-13-3 ]

CAS No. :5913-13-3
Formula : C8H17N
M.W : 127.23
SMILES Code : C[C@@H](N)C1CCCCC1
MDL No. :MFCD00043338
InChI Key :XBWOPGDJMAJJDG-SSDOTTSWSA-N
Pubchem ID :10997046

Safety of [ 5913-13-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H302+H312-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8(3)
UN#:2734
Packing Group:
 

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