Home Cart Sign in  
Chemical Structure| 581-00-0 Chemical Structure| 581-00-0

Structure of 581-00-0

Chemical Structure| 581-00-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 581-00-0 ]

CAS No. :581-00-0
Formula : C11H16N2O
M.W : 192.26
SMILES Code : NC1=CC=C(N2CCOCC2)C=C1C
MDL No. :MFCD10686817

Safety of [ 581-00-0 ]

Application In Synthesis of [ 581-00-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 581-00-0 ]

[ 581-00-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 98556-31-1 ]
  • [ 581-00-0 ]
  • (6-iodo-quinazolin-4-yl)-(2-methyl-4-morpholin-4-yl-phenyl)-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% In acetonitrile;Heating / reflux; Step3: A suspension of 4-chloro-6-iodo-quinazoline (500mg, 1.8mMol) and 2- methyl-4-morpholin-4-yl-phenylamine (360mg, 1.9mMol) in acetonitrile (3ml) was heated at reflux overnight, during which a precipitate developed. The reaction was cooled and the precipitate filtered off. This was washed with 1M sodium hydroxide solution and water before being air dried to give (6-iodo-quinazolin-4-yl)-(2-methyl-4- morpholin-4-yl-phenyl)-amine(738mg , 95%). LC/MS: RT- 3.55, MH+ 447 5 (DMSO) 10.35 (1H, br s); 9.04 (1H, d, 1.3Hz); 8.55 (lH, s); 8.20 (1H, dd, J 8.8Hz, 1.3Hz); 7.60 (1H, d, J 8.8Hz); 7.14 (1H, d, J 8.8Hz) ; 6.92 (1H, d, J 2.5); 6.87 (IH, dd, J 8.2Hz, 1.9Hz); 3.77 (4H, t, 4.4Hz); 3.15 (4H, t, 4.4Hz) ; 2.15 (3H, s)
  • 2
  • [ 581-00-0 ]
  • [ 313340-08-8 ]
  • 5-chloro-6-ethyl-3-[2-methyl-4-(morpholin-4-yl)phenyl]amino}pyrazine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
660 mg With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 110℃; Preparation Example 238 A mixture of <strong>[313340-08-8]3,5-dichloro-6-ethylpyrazine-2-carboxamide</strong> (630 mg), 2-methyl-4-(morpholin-4-yl)aniline (500 mg), diisopropylethylamine (900 muL), and N-methylpyrrolidone (5 mL) was stirred at 110 C. overnight. The reactant was left to be cooled, and then water was added thereto, followed by extraction with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=8:2?5:5) to obtain 5-chloro-6-ethyl-3-[2-methyl-4-(morpholin-4-yl)phenyl]amino}pyrazine-2-carboxamide (660 mg) as an orange solid.
 

Historical Records

Technical Information

Categories