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Chemical Structure| 57824-30-3 Chemical Structure| 57824-30-3

Structure of 57824-30-3

Chemical Structure| 57824-30-3

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Product Details of [ 57824-30-3 ]

CAS No. :57824-30-3
Formula : C8H13N3O2S
M.W : 215.27
SMILES Code : O=S(C1=CC=C(N)C(N)=C1)(N(C)C)=O
MDL No. :MFCD00567917

Safety of [ 57824-30-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 57824-30-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57824-30-3 ]

[ 57824-30-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57824-30-3 ]
  • [ 57592-42-4 ]
  • [ 1192251-67-4 ]
YieldReaction ConditionsOperation in experiment
2-(2'-Fluorobiphenyl-4-yl)-7VJV-dimethyl-lH-benzimidazole-6-sulfonamide Into a 25 mL round-bottom flask equipped with a magnetic stirbar was added 3,4- diamino-vV,./V-dimethylbenzenesulfonamide (1.00 g, 4.7 mmol). To this was added a solution of <strong>[57592-42-4]2'-fluorobiphenyl-4-carbaldehyde</strong> (from Example 1, step 1, 800 mg, 4.0 mmol) in DMF (10 mL) and the reaction mixture stirred at room temperature for 5 min. Chlorotrimethylsilane (1.28 mL, 10.0 mmol) was added dropwise and the reaction mixture stirred for an additional 5 min, and <n="41"/>then heated to 90 0C in a reaction block for 16 h. The reaction mixture was cooled to room temperature and quenched with dropwise additon of 2M aqueous Na2CO3. The mixture was poured into a 250 mL separatory funnel containing water (75 niL) and the mixture was extracted with dichloromethane (3 x 50 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and the solvent was evaporated under reduced pressure. Purification by column chromatography through silica gel, eluting with 25% EtOAc in hexanes to 100% EtOAc in hexanes as a gradient over 35 min, yielded the title compound as a foam. MS (ESI, Q+) m/z 396 (M+l).
 

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