Structure of 578-57-4
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Transition-Metal-Free Borylation of Aryl Bromide Using a Simple Diboron Source
Lim, Taeho ; Ryoo, Jeong Yup ; Han, Min Su ;
Abstract: In this study, we developed a simple transition-metal-free borylation reaction of aryl bromides. Bis-boronic acid (BBA), was used, and the borylation reaction was performed using a simple procedure at a mild temperature. Under mild conditions, aryl bromides were converted to arylboronic acids directly without any deprotection steps and purified by conversion to trifluoroborate salts. The functional group tolerance was considerably high. The mechanism study suggested that this borylation reaction proceeds via a radical pathway.
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Purchased from AmBeed: 20469-65-2 ; 13675-18-8 ; 2564-83-2 ; 872-31-1 ; 192863-35-7 ; 871231-46-8 ; 192863-36-8 ; 6793-92-6 ; 3972-65-4 ; 2398-37-0 ; 850623-47-1 ; 929626-22-2 ; 705254-31-5 ; 580-13-2 ; 2635-13-4 ; 623-12-1 ; 1015082-71-9 ; 52415-29-9 ; 23145-07-5 ; 619-42-1 ; 99-90-1 ; 192863-37-9 ; 578-57-4 ; 407-14-7 ; 216434-82-1 ; 668984-08-5 ; 423118-47-2 ; 108-85-0 ; 252726-24-2 ; 101-55-3 ; 850623-36-8 ; 4923-87-9 ; 1394827-04-3 ; 850623-42-6 ; 438553-44-7 ; 460-00-4 ; 1187951-62-7 ; 705254-34-8 ; 111-83-1 ; 111-83-1 ; 906007-40-7 ; 1443282-44-7 ; 1000160-76-8 ; 1111733-01-7 ; 99-90-1
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CAS No. : | 578-57-4 |
Formula : | C7H7BrO |
M.W : | 187.03 |
SMILES Code : | COC1=CC=CC=C1Br |
MDL No. : | MFCD00000064 |
InChI Key : | HTDQSWDEWGSAMN-UHFFFAOYSA-N |
Pubchem ID : | 11358 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 9 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.14 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 1.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 40.63 |
TPSA ? Topological Polar Surface Area: Calculated from |
9.23 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.2 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
2.86 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.46 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
2.57 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
2.52 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.52 |
Log S (ESOL):? ESOL: Topological method implemented from |
-3.23 |
Solubility | 0.11 mg/ml ; 0.000591 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.71 |
Solubility | 0.362 mg/ml ; 0.00194 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.38 |
Solubility | 0.0783 mg/ml ; 0.000419 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.41 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.1 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With chlorosulfonic acid; In dichloromethane; at -5 - 20℃; for 1.5h; | L-BROMO-2-METHOXY-BENZENE (1.87 g, 10.0 mmol) was dissolved in chloroform (5 mL) and the solution was cooled in an ice-salt bath to-5 C to 0 C. The cooled solution was carefully charged with CHLOROSULFONIC acid (2.0 mL, 30.0 mmol) over 30 minutes and the mixture was allowed to warm to room temperature over 1 hour. The mixture then was poured onto chopped ice and transferred to a separatory funnel. The aqueous layer was separated and extracted (X2). The combined organic layers were dried and concentrated to give 3-bromo-4-methoxyphenylsulfonyl chloride (2.80 g, 98%). 3-Bromo-4-methoxyphenylsulfonyl chloride (2.80 g, 9.8 mmol) was dissolved in dichloromethane (30 mL) and the solution was treated with triethylamine (1.76 mL, 12.6 mmol), followed by the dropwise addition of t-butylamine (1.33 mL, 12.6 mmol). The mixture was allowed to stand for 2 hours and then was poured onto a mixture of 5% citric acid solution and dichloromethane. The organic layer was separated and the aqueous layer was extracted with dichloromethane/ (X2). The combined organic layers were dried and concentrated. Crystallization of the crude solid from ethyl acetate/hexane gave 3-BROMO-N- tert-butyl-4-methoxybenzenesulfonamide (2.43 g, 77%) |
98% | With chlorosulfonic acid; In chloroform; at -7 - 20℃; for 1.5 - 1.83333h;Product distribution / selectivity; | o-Bromoanisole (1.87 g, 10. OMMOL) was dissolved in chloroform (5 mL) and the solution was cooled in an ice-salt bath to-5 C to 0 C. The solution was carefully charged with CHLOROSULFONIC acid (2.0 mL, 30.0 mmol) over 30 minutes and then allowed to warm to room temperature over 1 hour. The mixture was poured onto chopped ice and transferred to separatory funnel. The organic layer was separated and the aqueous layer was extracted, dried and concentrated to give 3-bromo-4-methoxyphenylsulfonyl chloride (2.80 g, 98%).; REFERENCE 17 N-TERT-BUTYL-4-METHOXY-3- (4, 4,5, 5-TETRAMETHYL- [1, 3,2] DIOXABOROLAN-2-YL) - BENZENESULFONAMIDE [0214] A 500 mL 3-necked flask, equipped with thermometer, overhead stirrer and a 60 mL DROPPING FUNNEL, WAS CHARGED WITH 2-BROMOANISOLE (46.8 G, 0.25 MOL, 1.0 EQ. ) AND ANHYDROUS chloroform (250 mL). The flask was flushed with nitrogen and cooled with a brine-ice cool- bath to an internal temperature of-7C and then chlorosulfonic acid (87.4 g, 0.75 mol, 3.0 EQ.) was added via dropping funnel over 1 hour while maintaining an internal temperature of less THAN-5C. The reaction mixture was stirred for 50 minutes and then poured on to ice (500 g). The mixture was stirred until the ice melted and then the organic layer was separated and washed with water (2 x 200 mL). The combined aqueous layers were backwashed with chloroform (2 x 200 mL) and the combined organic phases were washed with brine and dried (MGS04). [0215] The organic phase was treated at room temperature with triethylamine (87 mL, 63 g, 0.625 MOL, 2.5 EQ. ) AND THEN TERT-BUTYLAMINE (34 ML, 24 G, 0.325 MOL, 1.3 EQ. ). THE REACTION mixture was stirred overnight, cooled in an ice-bath and poured into ice cold 2M hydrochloric acid (500 mL). The organic layer was separated and washed with 2M hydrochloric acid (2 x 250 mL) and brine, dried (MGSO4) and concentrated. Crystallization of the residue from chloroform-hexane gave 3-BROMO-N-TERT-BUTYL-4-METHOXY-BENZENESULFONAMIDE (37.5 g, 47%) as brilliant white crystals. RP-HPLC (10-95S) RT = 3.92 MIN.'H NMR (400 MHz, d6- DMSO): 8 7. 94 (1H, d, J = 2. 4 HZ), 7.77 (1H, dd, J = 8. 8,2. 4 HZ), 7.48 (1H, s), 7.25 (1H, d, 8.8 Hz), 3.92 (3H, s), 1.08 (9H, s). [0216] A mixture OF 3-BROMO-N-TERT-BUTYL-4-METHOXY-BENZENESULFONAMIDE (36.2 g, 112 mmol, 1.0 eq), bis (pinocalto) diborane (30.0 g, 117 mmol, 1.05 EQ.), potassium acetate (33.0 G, 336 MMOL, 3.0 EQ. ) AND PDCL2 (DPPF)-DCM (533 MG, 0.653 MMOL, 5.8 MOL %, IN 115 ML of 1,4-dioxane) was heated at 100 C under nitrogen and then 4,4, 5,5, 4', 4', 5', 5'- OCTAMETHYL- [2, 2'] BI [ [1, 3, 2] DIOXABOROLANYL] (0.35 EQ. ) WAS ADDED TO THE MIXTURE. THE REACTION mixture was heated for 28 hours and then allowed to cool. The mixture was filtered of solids and concentrated. The residue was dissolved in ethyl acetate (500 mL) and the solution was washed with 5% citric acid (3x 200 mL), saturated sodium bicarbonate (3 x 200 mL) and then brine, dried (MGSO4) and concentrated. Purification of product from the residue by silica-gel chromatography, eluting with 10-50% EtOAc/Hex gave N-tert-butyl-4-methoxy-3- (4, 4,5, 5- TETRAMETHYL- [1, 3,2] DIOXABOROLAN-2-YL) -BENZENESULFONAMIDE (30 G, 72%) AS A PALE-ORANGE solid. RP-HPLC (10-95S): RT = 3.17 min.'HNMR (400MHz, d6-DMSO) : 57. 95 (1H, d, J = 2.4 Hz), 7.85 (1H, dd, J = 8.8, 2.4 Hz), 7.36 (1H, s), 7.11 (1H, d, J = 8.8), 3.81 (3H, s), 1.29 (12H, s), 1.07 (9H, s); M/Z (LCMS-ESI): Q+ 310 (boronic acid+Na), 370 (M+H), 392 (M+Na); Q~ 354 (M-Me), 556 (boronic acid anhydride). |
97% | With chlorosulfonic acid; In dichloromethane; at 0 - 20℃;Cooling with ice; | A solution of 2-bromoanisole (5.00 g, 26.7 mmol) in CH2Cl2 (100 mL) was cooled on ice. Chlorosulfonic acid (9.3 g, 80 mmol) in CH2Cl2 (100 mL) was added dropwise at 0 C. The reaction mixture was allowed to reach room temperature overnight and was then added slowly to a stirred solution of brine. The organic phase was separated and washed with brine, dried over MgSO4, filtered and concentrated. The intermediate 3-bromo-4-methoxybenzenesulfonyl chloride was obtained in 97% yield (7.33 g). 1H NMR (600 MHz, CDCl3) delta ppm 4.03 (s, 3H) 7.04 (d, J=8.85 Hz, 1H) 7.99 (dd, J=8.85, 2.44 Hz, 1H) 8.22 (d, J=2.44 Hz, 1H). MS (ESI+) m/z 249 [M-Cl]+. |
With chlorosulfonic acid; In chloroform; at -10 - 20℃; for 1h; | 10 g of 1-bromo-2-methoxybenzene was dissolved in chloroform (56 mL), and then chlorosulfuric acid (11 mL, 3 equivalents) was added thereto at -10 C., followed by stirring at room temperature for 1 hour. The formation of the product was confirmed by TLC, and then the reaction mixture was poured into distilled water under ice-cooling, followed by extraction using ethyl acetate. Thereafter, the organic phase was dried over anhydrous magnesium sulfate, followed by filtration, and thus obtaining as a crude product 14 g of the title compound by vacuum concentration of the filtrate.MS (ESI) m/z: 285 (M+H)+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sodium carbonate; In N,N-dimethyl-formamide; at 120℃; | General procedure: A solution containing K4[Fe(CN)6] (0.2 mmol), aryl halide (1.0 mmol), Na2CO3 (1.5 mmol), Pd(at)CS-biguanidine (50 mg,0.7 mol%), and DMF (3 ml) was mixed under stirring at 120 C for the specified time. TLC was used to follow the reaction. At the end of the reaction, the obtained solution was cooled to ambient temperature and centrifuged, and the residue was rinsed using ethyl acetate (3 10 ml). Water phase containing ethyl acetate (30 mL) was mixed with the organic phase to extract the ethyl acetate from the water. The organic phase was dried over Na2SO4. The products were resulted by evaporating the organic solvent. If more purification was needed, the products were passed through a short silica gel column using the eluent of n-hexane. All the products are known substances and were compared with authentic specimens. |
88% | With sodium carbonate; In N,N-dimethyl-formamide; at 120℃; for 2h;Catalytic behavior; | General procedure: A solution containing K4[Fe(CN)6] (0.17 mmol), aryl halide (1.0mmol), Na2CO3 (1.5 mmol), Fe3O4PMDP/Pd (45 mg, 1.5 mol%),and DMF (3 mL) was mixed under stirring at 120 C for the specifiedtime. TLC was used to follow the reaction. At the end of thereaction, the obtained solution was cooled to ambient temperatureand filtered, and the residue was rinsed using ethyl acetate (3 10mL) to isolate the catalyst using a suitable magnet. Water phasecontaining ethyl acetate (30 mL) was mixed with the organic phaseto extreact the ethyl acetate from the water. The organic phase wasdried over Na2SO4. The products were resulted by evaporating theorganic solvent. If more purification was needed, the productswere passed through a short silica gel column using the eluent ofn-hexane. All the products are known substances and were comparedwith authentic specimens |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42%Chromat. | General procedure: In an oven dried 25 ml two-necked round-bottom flask equipped with a condenser was placed a mixture of aryl halide (1 mmol), [Rh(cod)Cl]2 (0.05 mmol, 5 mol %), and Xantphos (0.1 mmol, 10 mol %) in 10 ml/mol formamide at room temperature and stirred for 2-3 min. Then POCl3 (2 mmol) was added to the reaction mixture which was then heated in an oil bath at 135-140 C for 24 h with continuous stirring under nitrogen atmosphere. After 24 h the reaction mixture was cooled to room temperature and poured into 40 ml saturated solution of NaHCO3. The product was extracted into ethyl acetate (3 × 15 ml). After drying over anhydrous Na2SO4, the combined ethyl acetate layer was concentrated by rotary evaporation. All the prepared compounds were characterized by GC-MS (Shimadzu QP 2010). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21%Chromat. | With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); sodium t-butanolate; In N,N-dimethyl-formamide; at 130℃; for 24h; | General procedure: A mixture of aryl bromides (0.250 mmol), malonontrile (0.500 mmol),palladium catalyst (0.005 mmol), CuI (0.125 mmol), 1,10-phenanthroline (0.063mmol), t-BuONa (0.500 mmol) and KF (0.500 mmol) in DMF or NMP (1 mL) is stirred at 130 C for 24 h. Upon completion, the reaction mixture is diluted with EtOAc (4.0 mL), filtered through a bed of silica gel layered over Celite, The volatiles are removed in vacuo to afford the crude product. The extent of conversions is determined by GC. Further column chromatography on silica gel affords the pure desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With bis[1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenyl-1,2,3-triazol-5-ylidene]palladium(II) iodide; potassium tert-butylate; In ethanol; at 20℃; for 3h;Inert atmosphere; | General procedure: Bromo compound (0.5 mmol, 1eq), boronic acid ( 0.6mmol, 1.2 eq )was dissolved in absolute ethanol (10 mL) in a 25 mL two neck flask . The contents of the flask were degassed with nitrogen. Potassium t-butoxide (0.75 mmol, 1.5 eq) was added followed by (0.5 mol %) of the complex, [Bis[1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methyl-4-phenyl-1,2,3-triazol-5-ylidene]palladium (II) iodide (11)]. The contents of the flask were stirred at room temperature under nitrogen atmosphere. The reaction was monitored by thin layer chromatography. After completion of the reaction (disappearance of the bromo compound) solvent was evaporated and the residue was dissolved in water (20 mL) and extracted with dichloromethane (3 x 20 mL). The dichloromethane layer was washed with saturated sodium chloride solution (20 mL) and water (20 mL). The organic layer was evaporated; the compound was purified by column chromatography using hexane as solvent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sodium hydroxide; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; water; at 100℃; for 1h;Inert atmosphere; Microwave irradiation; | General procedure: In a microwave tube were added a suspension of Pd(dba)2 (5mol%), tBu3PHBF4 (10mol%), NaOH (2eq), aryl bromide (1.2eq) and alpha-tetralone (1.0eq) in a mixture of degassed dioxane/water (4:1, v/v, 2-4mL) and heated under Ar and microwave irradiation (100W of initial power, 100C, 60min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude material was purified by silica gel column with n-hexane:AcOEt (95:5) as solvent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | General procedure: To a solution of 4-bromobiphenyl 1a (3.0 mmol, 699.3 mg) in THF (3.0 mL) was added n-BuLi (4.5 mmol, 1.55 M in hexane, 2.87 mL) at 50 C. The obtained mixture was stirred for 30 min at 50 C under an argon atmosphere. Pivalonitrile (6.0 mmol, 498.8 mg) in THF (2.0 mL) was added to the mixture at 50 C and the obtained mixture was stirred for 30 min in the temperature range of 50 C to room temperature. MeOH (2.0 mL) was added to the mixture. Then, I2 (12.0 mmol, 3045.6 mg) and K2CO3 (12.0 mmol, 1658.4 mg) were added to the mixture at room temperature, and the obtained mixture was stirred for 6 h at 70 C. Sat. aq. Na2SO3 solution (20.0 mL) was added to the reaction mixture, and the product was extracted with AcOEt (10.0 mL x 3). The organic layer was dried over Na2SO4. After filtration and removal of the solvent, the residue was purified by silica-gel column chromatography (chloroform: n-hexane 1:1) to give 4-cyanobiphenyl 2a (451.6 mg, 84%). |
Tags: 578-57-4 synthesis path| 578-57-4 SDS| 578-57-4 COA| 578-57-4 purity| 578-57-4 application| 578-57-4 NMR| 578-57-4 COA| 578-57-4 structure
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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