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Chemical Structure| 5768-79-6 Chemical Structure| 5768-79-6

Structure of 5768-79-6

Chemical Structure| 5768-79-6

Tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione

CAS No.: 5768-79-6

4.5 *For Research Use Only !

Cat. No.: A709340 Purity: 96%

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Product Details of [ 5768-79-6 ]

CAS No. :5768-79-6
Formula : C6H8N2O2
M.W : 140.14
SMILES Code : O=C(N1)C(CCC2)N2C1=O
MDL No. :MFCD01851016

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Application In Synthesis of [ 5768-79-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5768-79-6 ]

[ 5768-79-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 5768-79-6 ]
  • [ 6943-97-1 ]
  • [ 92763-94-5 ]
  • 2
  • [ 5768-79-6 ]
  • [ 60211-57-6 ]
  • [ 336818-18-9 ]
YieldReaction ConditionsOperation in experiment
With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20℃; for 0.75h; Step 1: To a solution of 1,3-diazabicyclo[3.3.0]octane-2,4-dione 1 (500 mg, J, Med. Chem., 1995, 38, 3566), PPh3 (1.2 g) and <strong>[60211-57-6]3,5-dichlorobenzyl alcohol</strong> (690 mg) in THF (10 mL) at 0C was added DEAD (0.7 mL) drop-wise over 45 minutes. The mixture was allowed to warm to room temperature and H2O /EtOAc (50 mL each) were added and the mixture was shaken. The aqueous phase was then separated and extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by chromatography (SiO2, EtOAc/Hexanes) and recrystallization from EtOH/H2O to give the desired N-benzyl derivative 2 (550 mg). MS (m/z) 299 (M+).
 

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