Home Cart Sign in  
Chemical Structure| 57667-50-2 Chemical Structure| 57667-50-2

Structure of 57667-50-2

Chemical Structure| 57667-50-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 57667-50-2 ]

CAS No. :57667-50-2
Formula : C10H13N3
M.W : 175.23
SMILES Code : NC1=NC2=CC=CC=C2N1CCC
MDL No. :MFCD00964693
InChI Key :MGKUHRRJQCKXOW-UHFFFAOYSA-N
Pubchem ID :799602

Safety of [ 57667-50-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 57667-50-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57667-50-2 ]

[ 57667-50-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6066-82-6 ]
  • [ 23351-91-9 ]
  • [ 57667-50-2 ]
  • C22H19BrN4O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h; 5-Bromo-N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide 13. A mixture of <strong>[23351-91-9]5-bromoisophthalic acid</strong> (100 mg, 4.1 mumol), N-propylaminobenzamidazole (72 mg, 4.1 mumol), N-hydroxysuccinimide (56 mg, 4.9 mumol), DMAP (5 mg, 0.4 mumol) and EDC (234 mg, 1.2 mmol) were dissolved in methylene chloride (5 mL), treated with Hunig's base (53 mg, 4.1 mumol) and stirred for 1 d to give 12. The reaction mixture was then treated with 9/1 MeOH/NH4OH (5 mL) and stirred for 2 h. The mixture was concentrated to a solid, dissolved in DMSO, added to a column and chromatographed (50 g isco C18, 0 to 100percent MeOH with 0.2percent formic acid) to give 13 (71 mg, 43percent) as a white powder. LC/MS gave a single peak with m/z=401.1 [M+1]+ and 823.1 [2M+Na]+. 1H-NMR (dmso-d6) delta 12.77 (br s, 1H), 8.65 (br s, 1H), 8.45 (br s, 1H), 8.22 (br s, 1H), 8.17 (br s, 1H), 7.54-7.60 (m, 3H), 7.28 (t, J=8 Hz, 1H), 7.24 (t, J=8 Hz, 1H), 4.27 (t, J=7 Hz, 2H), 1.85 (h, J=7 Hz, 2H), 0.92 (t, J=7 Hz, 3H).
  • 2
  • [ 4481-28-1 ]
  • [ 57667-50-2 ]
  • N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% 3-Carbamoylbenzoic acid (1 g, 0.006 mol) was dissolved in 10 mE of dry dimethylformamide (DMF) while stirring in a round bottom flask. HI3TU (2.73 g, 0.0072 moO/HOST hydrate (1.195 g, 0.0078 mol) solution was made with 15 mE DMF. HETU/HOST was added to the solution in the round bottom flask. 1 -propylbenzimidazol2-amine (1.157 mg, 0.0066 mol) in 15 mE DMF was injected and the solution was stirred for 20 minutes at room temperature. 4-methylmorpholine (1.98 mE, 0.018 mol) was added to the round bottom flask by syringe. The mixture was stirred until reaction completion (.- 12 hrs.). The reaction was quenched with 10 mE of deionized (DI) watet A precipitate was formed and isolated by vacuum filtration and washed with 10 mE of DI water to give the final product. Yield 1.56 g (80% yield)
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 57667-50-2 ]

Amines

Chemical Structure| 90871-47-9

A139395 [90871-47-9]

2-Amino-1-isopropylbenzimidazole

Similarity: 0.93

Chemical Structure| 2851-13-0

A272098 [2851-13-0]

N,N-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.90

Chemical Structure| 934-32-7

A106367 [934-32-7]

1H-Benzo[d]imidazol-2-amine

Similarity: 0.86

Chemical Structure| 945021-49-8

A173036 [945021-49-8]

1,7-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.86

Chemical Structure| 39860-12-3

A283410 [39860-12-3]

1,5-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.86

Related Parent Nucleus of
[ 57667-50-2 ]

Benzimidazoles

Chemical Structure| 90871-47-9

A139395 [90871-47-9]

2-Amino-1-isopropylbenzimidazole

Similarity: 0.93

Chemical Structure| 2851-13-0

A272098 [2851-13-0]

N,N-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.90

Chemical Structure| 934-32-7

A106367 [934-32-7]

1H-Benzo[d]imidazol-2-amine

Similarity: 0.86

Chemical Structure| 945021-49-8

A173036 [945021-49-8]

1,7-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.86

Chemical Structure| 39860-12-3

A283410 [39860-12-3]

1,5-Dimethyl-1H-benzo[d]imidazol-2-amine

Similarity: 0.86