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Chemical Structure| 5736-03-8 Chemical Structure| 5736-03-8

Structure of 5736-03-8

Chemical Structure| 5736-03-8

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Product Details of [ 5736-03-8 ]

CAS No. :5736-03-8
Formula : C6H10O3
M.W : 130.14
SMILES Code : O=CC1OC(C)(C)OC1
MDL No. :MFCD08460236
InChI Key :YSGPYVWACGYQDJ-UHFFFAOYSA-N
Pubchem ID :110702

Safety of [ 5736-03-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H303-H411-H225
Precautionary Statements:P501-P273-P240-P210-P233-P243-P241-P242-P280-P370+P378-P312-P391-P303+P361+P353-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 5736-03-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5736-03-8 ]

[ 5736-03-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 651-06-9 ]
  • [ 5736-03-8 ]
  • 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylene]amino}-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide [ No CAS ]
  • 2
  • [ 14062-29-4 ]
  • [ 5736-03-8 ]
  • C16H21ClO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of 32.5 mmoles of LDA (prepared by the addition of 20.4 mL of 1.6 molar nBuLi to 4.98 mL of diisopropylamine in 90 mL of THF at 0 C.) was added dropwise a solution of phenyl acetates of formula (3) wherein R1=R2=H, Br, Cl, F and/or methoxy (35.8 mmole) in 20 mL of THF at -78 C. The resulting mixture was stirred at that temperature for 30 minutes followed by the addition of 8 mL of HMPA and stirred for further 20 minutes. To this mixture was added dropwise a solution of aldehyde of formula (2) (5.8 g, 32.5 mmole) in 20 mL of THF and the stirring was continued at -78 C. for 1 h. The reaction mixture was allowed to warm to room temperature followed by quenching with ammonium chloride solution. The reaction mixture was diluted with 100 mL of ethyl acetate, washed with water (2×100 mL), 1 N HCl solution (2×50 mL), water (2×100 mL), dried over Na2SO4 and concentrated. The residue was purified by column chromatography to afford the hydroxy ester of formula (4) as a pale yellow pasty mass. Yield 50-60%.
  • 3
  • [ 5736-03-8 ]
  • [ 5736-06-1 ]
 

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