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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 5728-52-9 Chemical Structure| 5728-52-9
Chemical Structure| 5728-52-9

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4-Biphenylacetic acid is used in the synthesis of gastrosparing non-steroidal antiinflammatory drug as a potential non-steroidal antiinflammatory agent.

Synonyms: Felbinac

4.5 *For Research Use Only !

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Product Details of 4-Biphenylacetic Acid

CAS No. :5728-52-9
Formula : C14H12O2
M.W : 212.24
SMILES Code : O=C(O)CC1=CC=C(C2=CC=CC=C2)C=C1
Synonyms :
Felbinac
MDL No. :MFCD00004351
InChI Key :QRZAKQDHEVVFRX-UHFFFAOYSA-N
Pubchem ID :3332

Safety of 4-Biphenylacetic Acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H331-H315-H319-H335
Precautionary Statements:P261-P264-P301+P310-P302+P352-P304+P340+P311-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of 4-Biphenylacetic Acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5728-52-9 ]

[ 5728-52-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5728-52-9 ]
  • [ 2895-21-8 ]
  • N-isopropylcarbamoylmethyl 4-biphenylacetate [ No CAS ]
  • 2
  • [ 5728-52-9 ]
  • [ 13130-79-5 ]
  • 2-biphenyl-4-yl-N-(1-bromo-isoquinolin-3-yl)-acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% To a solution of 4-biphenylacetic acid (1. [0G,] 4.7 [MMOL)] in 10 mi of anhydrous DMF was added HBTU (2.1g, 5.7 [MMOL)] and 1.0 ml of DIEA. The mixture was stirred at room temperature for 10 min, and then <strong>[13130-79-5]1-bromo-3-isoquinolinamine</strong> (0.68g, 4.7 [MMOL)] was added. After stirring over night, the mixture was poured into water, acidified with 10% citric acid, and extracted with ethyl acetate. The organic extracts were washed with water and brine, dried over [NA2SO4.] After the condensation of the solvent, the residue was purified by flash column chromatography [(SIO2,] 1: [1] hexane: ethyl aceate) to provide the title compound (1.7g, 86%) as a light yellow solid. 'H-NMR (400 MHz, [CDC . S)] : 3.83 (s, 3H), 7.33-7. 37 (m, 1H), 7.42-7. 48 (m, 4H), 7.52- 7.58 (m, 1 H), 7.60-7. 64 (m, 4H), 7.65-7. 70 (m, 1 H), 7.80 (d, 1 H,), 7. [61] (s, 1H), 8.18 (d, 1 H), 8.56 (s, 1H) ; LC/MS (m/z) : 418 (M+1) [+.]
  • 3
  • [ 5728-52-9 ]
  • [ 27644-00-4 ]
 

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