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Chemical Structure| 57235-35-5 Chemical Structure| 57235-35-5

Structure of 57235-35-5

Chemical Structure| 57235-35-5

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Product Details of [ 57235-35-5 ]

CAS No. :57235-35-5
Formula : C6H8N2O2S
M.W : 172.20
SMILES Code : SC1=NC(OC)=CC(OC)=N1
MDL No. :MFCD00672150
InChI Key :PCVRHOZHSQQRMC-UHFFFAOYSA-N
Pubchem ID :10313510

Safety of [ 57235-35-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 57235-35-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57235-35-5 ]

[ 57235-35-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 124-63-0 ]
  • [ 178306-47-3 ]
  • [ 57235-35-5 ]
  • methyl 2-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methoxy-3,3-diphenylpropionate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; triethylamine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; N,N-dimethyl-formamide; EXAMPLE 7 Methyl 2-(4,6-dimethoxy-pyrimidin-2-ylthio)-3-methoxy-3,3-diphenylpropionate 7.16 g (25 mmol) of <strong>[178306-47-3]methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate</strong> were dissolved in 50 ml of dichloromethane, 3 g (30 mmol) of triethylamine were added, and 3.2 g (28 mmol) of methane-sulfonyl chloride were added dropwise while stirring. The mixture was stirred at room temperature for 2 h., washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The residue was taken up in DMF and added dropwise at 0 C. to a suspension of 12.9 g (75 mmol) of 4,6-dimethoxypyrimidine-2-thiol and 8.4 g (100 mmol) of sodium bicarbonate in 100 ml of DMF. After stirring at room temperature for 2 h. and at 60 C. for a further 2 h., the mixture was poured into 1 liter of ice-water, and the resulting precipitate was filtered off with suction. After drying, 3.19 g (29%) of a white powder remained.
  • 2
  • sodium hydrosulfide·NH2O [ No CAS ]
  • [ 35144-22-0 ]
  • [ 57235-35-5 ]
YieldReaction ConditionsOperation in experiment
In methanol; acetonitrile; Example IV-1 A solution (250 ml) of sodium hydrosulfide·nH2O (purity: about 70%; 35.0 g) in methanol was added at room temperature under stirring to a solution of 4,6-dimethyl-2-methylsulfonyl pyrimidine (50.0 g in acetonitrile (400 ml). The reaction mixture was stirred at room temperature for 3 hours, and then the solvent was distilled off under reduced pressure. The resultant residue was admixed with water, and insoluble matters were removed by filtration. The solution thus obtained was acidified with concentrated hydrochloric acid to crystallize out the desired compound, which was then separated by filtration, washed with water and dried to give 4,6-dimethoxy-2-mercaptopyrimidine (37.5 g). The purity of this product was 98%. Yield: 95%. mp. >300C
  • 3
  • [ 178306-47-3 ]
  • [ 57235-35-5 ]
  • methyl 2-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methoxy-3,3-diphenylpropionate [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate 7.1 6 g (25 mmol)Was dissolved in 50 ml of dichloromethane,3 g (30 mmol) of triethylamine was added,3.2 g (28 mmol) of methanesulfonyl chloride was added dropwise with stirring.The mixture was stirred at room temperature for 2 hours,Wash with water,Dried over magnesium sulfate,And concentrated under reduced pressure.The residue was placed in DMF,At 0 C., 12.9 g (75 mmol) of 4,6-dimethoxypyrimidine-2-thiol,And 8.4 g (100 mmol) of sodium bicarbonate,Was added dropwise to a suspension of 100 ml of DMF.2 hours at room temperature,After further stirring at 60 C. for 2 hours,The mixture was poured into 1 l of ice water and the resulting precipitate was filtered off with suction.When dried,3.19 g (29%) of a white powder remained.
 

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