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Chemical Structure| 571189-64-5 Chemical Structure| 571189-64-5

Structure of 571189-64-5

Chemical Structure| 571189-64-5

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Product Details of [ 571189-64-5 ]

CAS No. :571189-64-5
Formula : C15H18N4O2
M.W : 286.32
SMILES Code : O=C1C(C(C)=O)=C(C)C2=CN=C(N)N=C2N1C3CCCC3

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 571189-64-5 ]

[ 571189-64-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 571189-64-5 ]
  • [ 492431-11-5 ]
  • tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridazin-3-yl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 150℃; for 1.0h;Microwave irradiation; Synthesis of tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridazin-3-yl)piperazine-1-carboxylate To a solution of acetyl-2-amino-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one (114 mg, 0.40 mmol) in 1,4-dioxane (4 mL) were added <strong>[492431-11-5]tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate</strong> (143 mg, 0.48 mmol), tris(dibenylideneacetone)dipalladium (0) (18.4 mg, 0.02 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (35 mg, 0.06 mmol), sodium t-butoxide (58 mg, 0.60 mmol). The mixture thus obtained was heated for 1 h at 150 C. under microwave irradiation. The reaction mixture was passed through short pack silica gel column and was concentrated to give a crude product as a yellow solid (153 mg, purity: 50-60%) which was used in next step without any further purification. MS (ESI) m/z: 549.3 [M+H]+.
 

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