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Chemical Structure| 57052-99-0 Chemical Structure| 57052-99-0

Structure of 57052-99-0

Chemical Structure| 57052-99-0

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Product Details of [ 57052-99-0 ]

CAS No. :57052-99-0
Formula : C10H9NO6
M.W : 239.18
SMILES Code : O=C(OC)C1=CC=CC(C(OC)=O)=C1[N+]([O-])=O
MDL No. :MFCD18651700
InChI Key :UZMFVOACDBUXRK-UHFFFAOYSA-N
Pubchem ID :12217542

Safety of [ 57052-99-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330

Application In Synthesis of [ 57052-99-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57052-99-0 ]

[ 57052-99-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57052-99-0 ]
  • [ 57053-02-8 ]
YieldReaction ConditionsOperation in experiment
99% With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20℃; for 20h; Dimethyl 2-aminoisophtalate X (where R1 is methyl). A stream of hydrogen was bubbled through a solution of nitroarene XIV (130 g, 544 mmol, 1.0 eq) and Pd/C (10%,dry, 7.95 g, 6.31 mmol, 1.2 mol%) in regular ethyl acetate (1450 mL) at room temperature. Completion was obtained within 20 h as indicated by TLC analysis. However the reaction time greatly varied depending on the scale and conditions used. The mixture was filtered through a sintered funnel and Pd/C was recovered and successfully reused in other hydrogenations. In the case where wet Pd/C was used,the filtrate was first dried over anhydrous sodium sulphate. The solvents were removed under vacuum to give the desired aniline X (where R1 is methyl) (113 g, 99%) in excellent purity and as a smelly off-white powder. (CAS 57053-02-3)
 

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