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Chemical Structure| 57002-01-4 Chemical Structure| 57002-01-4

Structure of 57002-01-4

Chemical Structure| 57002-01-4

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Product Details of [ 57002-01-4 ]

CAS No. :57002-01-4
Formula : C8H15BO2
M.W : 154.01
SMILES Code : OB(/C=C/C1CCCCC1)O
MDL No. :MFCD01074615

Safety of [ 57002-01-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 57002-01-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 57002-01-4 ]

[ 57002-01-4 ] Synthesis Path-Downstream   1~35

  • 2
  • [ 57002-01-4 ]
  • [ 67404-69-7 ]
  • 3
  • [ 57002-01-4 ]
  • [ 67478-59-5 ]
  • 4
  • [ 57002-01-4 ]
  • E,E-4-[R*,R*-5-(2,2-Dibromoethenyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-phenyl-1,3-pentadiene [ No CAS ]
  • E,E-4-[R*,R*-5-(1E,3E-2-Bromo-4-cyclohexyl-1,3-butadienyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-phenyl-1,3-pentadiene [ No CAS ]
  • E,E-4-[R*,R*-5-(1Z,3E-2-Bromo-4-cyclohexyl-1,3-butadienyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-phenyl-1,3-pentadiene [ No CAS ]
  • 6
  • [ 880263-69-4 ]
  • [ 57002-01-4 ]
  • [ 880263-77-4 ]
  • 7
  • [ 929078-65-9 ]
  • [ 57002-01-4 ]
  • 5-cyclohexyl-3-ethyl-penta-2,4-dienoic acid methyl ester [ No CAS ]
  • 8
  • [ 57002-01-4 ]
  • [ 431-03-8 ]
  • C12H20O2 [ No CAS ]
  • 9
  • [ 938433-81-9 ]
  • [ 57002-01-4 ]
  • [ 936760-51-9 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 90℃; for 6.5h; Preparation of 1-[3-((E)-2-cyclohexylvinyl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (Reaction According to Scheme 6) 99.6 mg of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.40 mmol), 73.6 mg of cyclohexylvinylboronic acid (0.48 mmol), 84.4 mg of sodium carbonate (0.80 mmol) and 33.4 mg of [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.04 mmol) were initially charged in 6 ml of dimethylformamide/water (1:1) under nitrogen. The mixture was then heated to 90 C. for 6.5 h. Distilled water was then added to the reaction mixture and the resulting precipitate was filtered off with suction. The further purification was effected by column chromatography on silica gel (ethyl acetate/heptane eluent mixture). A light brown solid was obtained. m.p.: 202-204 C. (decomp.) ESI-MS: found m/z=326.0 (M+H+); calc. 325 amu 1H NMR (d6-DMSO): delta=1.10-1.40 (m, 8H), 1.65-1.90 (m, 5H), 2.28-2.38 (m, 1H), 3.25-3.35 (m, 2H), 6.69 (d, 1H), 7.15 (dd, 1H), 7.58 (d, 1H), 8.28 (d, 1H), 8.98 (s, 1H), 9.15 (s, 1H), 10.05 (s, 1H) ppm.
  • 10
  • [ 916672-81-6 ]
  • [ 57002-01-4 ]
  • C34H42N2O4 [ No CAS ]
  • 11
  • [ 1003321-67-2 ]
  • [ 57002-01-4 ]
  • C42H42N2O4 [ No CAS ]
  • 12
  • [ 16425-70-0 ]
  • [ 57002-01-4 ]
  • C32H38N2O4 [ No CAS ]
  • 13
  • [ 14011-60-0 ]
  • [ 57002-01-4 ]
  • C19H30N2O4 [ No CAS ]
  • 14
  • [ 64-17-5 ]
  • [ 57002-01-4 ]
  • [ 1029604-12-3 ]
  • 15
  • [ 869376-31-8 ]
  • [ 57002-01-4 ]
  • C25H32OSi [ No CAS ]
  • C25H32OSi [ No CAS ]
  • 16
  • [ 57002-01-4 ]
  • potassium (E)-2-(cyclohexyl)ethylenetrifluoroborate [ No CAS ]
  • 17
  • [ 1187833-88-0 ]
  • [ 57002-01-4 ]
  • [ 1187834-64-5 ]
YieldReaction ConditionsOperation in experiment
68% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 90℃; for 6h;Inert atmosphere; In a dried and purged vessel were added N-[(6-bromopyridin-2-yl)methoxy]-1-(1-methyl-1H-tetrazol-5- yl)-1-phenylmethanimine (0.2 g, 0.536 mmol, 1 eq.), <strong>[57002-01-4][(E)-2-cyclohexylvinyl]boronic acid</strong> (0.090 g, 0.58 mmol, 1.1 eq.), Na2CO3 (0.119 g, 1.12 mmol, 2.1 eq.) and Tetrakis(triphenylphosphine)palladium (0.030 g, 0.027 mmol, 0.05 eq.). A mixture of solvent was added toluene/ethanol/water (4/1/1 ) was added and the vessel purged with argon and sealed. The reaction was heated to 9OºC for 6 hrs. After cooling, 10 ml of EtOAc were added and the solids were filtered through a "Celite" plug and washed with EtOAc. The organics were separated, dried over MgSO4 and concentrated. The residue was <n="88"/>purified by chromatography on silica gel to give N-({6-[(E)-2-cyclohexylvinyl]pyridin-2-yl}methoxy)-1-(1- methyl-1H-tetrazol-5-yl)-1-phenylmethanimine (0.155 g, 68 % yield) as a colorless gum. HPLC/MS : m/z = 403 (M+H) ; logP(HCooH) = 5.05
  • 18
  • [ 623-12-1 ]
  • [ 57002-01-4 ]
  • [ 104151-26-0 ]
  • 19
  • [ 60785-20-8 ]
  • [ 57002-01-4 ]
  • [ 1257325-88-4 ]
  • 20
  • [ 573-57-9 ]
  • [ 57002-01-4 ]
  • [ 1313278-35-1 ]
  • C18H22O [ No CAS ]
  • 21
  • [ 19061-36-0 ]
  • [ 57002-01-4 ]
  • [ 1313278-41-9 ]
  • C20H26O [ No CAS ]
  • 22
  • [ 882746-92-1 ]
  • [ 57002-01-4 ]
  • (S)-(η6-5-bromo-8-(Z)-allylnaphthalene)tricarbonylchromium [ No CAS ]
  • (η6-5,8-((E)-(CHCHC6H11)2C10H6))tricarbonylchromium [ No CAS ]
  • 23
  • [ 1338718-68-5 ]
  • [ 57002-01-4 ]
  • (E)-tert-butyl 4-(5-(4-(butyloxycarbonylaminomethyl)piperidin-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2-cyclohexylvinyl)thiazol-5-ylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% With sodium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 130℃; for 0.75h;Inert atmosphere; Example 281 5-amino-N-(5-(4-(aminomethyl)piperidin-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-cyclohexylethyl)thiazole-4-carboxamide 281 A mixture of tert-butyl 4-(5-(4-(butyloxycarbonylaminomethyl)piperidin-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-bromothiazol-5-ylcarbamate (0.203 g, 0.33 mmol), Na2CO3 (70 mg, 0.66 mmol) and <strong>[57002-01-4]trans-(2-cyclohexylvinyl)boronic acid</strong> (0.102 g, 0.66 mmol) in DME (1.5 mL) and water (0.5 mL) was degassed by gently bubbling nitrogen through the mixture for 15 min. [1,1'-Bis(diphenylphosphino)ferrocene]dichloro-palladium(II) (27 mg, 0.033 mmol) was then added and the mixture degassed for a further 10 min before being heated in a microwave at 130 C. for 45 min. The reaction mixture was diluted with water and extracted with EtOAc. The combined organic extracts were passed through a phase separator cartridge and concentrated under reduced pressure. The residue was purified via silica gel column chromatography (0-100% EtOAc/isohexane) to afford (E)-tert-butyl 4-(5-(4-(butyloxycarbonylaminomethyl)piperidin-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2-cyclohexylvinyl)thiazol-5-ylcarbamate as a brown gum (0.144 g, 68%).
  • 24
  • [ 17084-13-8 ]
  • [ 1192147-21-9 ]
  • [ 57002-01-4 ]
  • (S)-(η5-pentamethylcyclopentadienyl)(η6-5-((E)-2-cyclohexylvinyl)naphthalene)ruthenium(II) hexafluorophosphate [ No CAS ]
  • 25
  • [ 1361582-80-0 ]
  • [ 57002-01-4 ]
  • [ 1361582-46-8 ]
  • 26
  • [ 1361582-91-3 ]
  • [ 57002-01-4 ]
  • [ 1361582-56-0 ]
  • 27
  • [ 1361582-94-6 ]
  • [ 57002-01-4 ]
  • 7-((R)-1-(Benzyloxy)propan-2-yl)-5-cyclohexyl-1-tosyl-2,3,4,5-tetrahydro-1H-indole [ No CAS ]
  • 28
  • [ 1361582-96-8 ]
  • [ 57002-01-4 ]
  • 5-cyclohexyl-7-((S)-2-methyl-4-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)butyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole [ No CAS ]
  • 29
  • [ 1393683-36-7 ]
  • [ 57002-01-4 ]
  • [ 1393683-49-2 ]
  • 30
  • ethyl 2-(2-tosylhydrazono)propanoate [ No CAS ]
  • [ 57002-01-4 ]
  • [ 1393683-45-8 ]
  • 31
  • [ 3240-34-4 ]
  • [ 57002-01-4 ]
  • [ 2926-30-9 ]
  • [ 1393725-23-9 ]
  • 32
  • [ 57002-01-4 ]
  • (S,E)-2-(2-cyclohexylvinyl)octan-1-ol [ No CAS ]
  • 33
  • [ 57002-01-4 ]
  • C16H28O [ No CAS ]
  • 34
  • [ 524-38-9 ]
  • [ 57002-01-4 ]
  • [ 1402704-17-9 ]
  • 35
  • [ 524-38-9 ]
  • [ 57002-01-4 ]
  • [ 1402704-56-6 ]
 

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