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Chemical Structure| 56686-16-9 Chemical Structure| 56686-16-9
Chemical Structure| 56686-16-9

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5-Bromo-2,4-dimethoxypyrimidine

CAS No.: 56686-16-9

4.5 *For Research Use Only !

Cat. No.: A115673 Purity: 98%

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Product Details of [ 56686-16-9 ]

CAS No. :56686-16-9
Formula : C6H7BrN2O2
Linear Structure Formula :C4HN2(OCH3)2Br
M.W : 219.04
SMILES Code : COC1=NC(OC)=NC=C1Br
MDL No. :MFCD00038016
InChI Key :QEZIMQMMEGPYTR-UHFFFAOYSA-N
Pubchem ID :255719

Safety of [ 56686-16-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 56686-16-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56686-16-9 ]

[ 56686-16-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56686-16-9 ]
  • [ 60186-89-2 ]
YieldReaction ConditionsOperation in experiment
To a stirred solution of LDA (2.0 M in THF/heptane/ethylbenzene) (25.8 mL, 51.5 mmol) in tetrahydrofuran (THF) (50 mL) at -78 C was added a solution of 5-bromo-2,4- dimethoxypyrimidine (10.3 g, 46.8 mmol) in THF (50 mL) dropwise. The mixture was stirred at -78C for 15 minutes. MeOH (10 mL) was added, the cooling bath was removed and the mixture stirred for 30 minutes. The reaction was quenched by addition of saturated Ammonium chloride (MLCl) solution (100 mL) and the mixture extracted with ethyl acetate (EtOAc) (3 x 40 mL). The organic extracts were combined and then dried over magnesium sulfate (MgSCri), filtered and concentrated in vacuo to afford the title compound 4-bromo- 2,6-dimethoxypyrimidine as an orange solid. The crude product was used directly in the next step.
 

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