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Chemical Structure| 5650-51-1 Chemical Structure| 5650-51-1

Structure of 5650-51-1

Chemical Structure| 5650-51-1

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Product Details of [ 5650-51-1 ]

CAS No. :5650-51-1
Formula : C7H6OS
M.W : 138.19
SMILES Code : O=C1CCC2=C1C=CS2
MDL No. :MFCD00757271
InChI Key :KOBLGOHFGYWCRC-UHFFFAOYSA-N
Pubchem ID :1958632

Safety of [ 5650-51-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 5650-51-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5650-51-1 ]

[ 5650-51-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5928-51-8 ]
  • [ 5650-51-1 ]
  • 2
  • [ 5650-51-1 ]
  • [ 2905-65-9 ]
  • 5-(3-chlorobenzoyl)-5,6-dihydrocyclopenta[b]thiophen-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% With sodium hydride; In tetrahydrofuran; mineral oil; at 100℃; for 8h; 5,6-Dihydro-cyclopenta[b]thiophen-4-one (2.1 g, 15.0 mmol) in 10 mL of THF was treated with NaH (60 percent, 0.73 g, 18 mmol). After the addition of 3-Chloro-benzoic acid methyl ester, the reaction mixture was heated at 100 C. for 8 hr. The solution was cooled to room temperature and poured into water. The resulting mixture was acidified with concentrated HCl and was added with ethyl acetate (80 mL). The organic layer was collected, brined, dried over MgSO4(s), and concentrated under reduced pressure. The resultant precipitate was collected and recrystallized from ethanol to provide the corresponding 5-(4-Chloro-benzoyl)-5,6-dihydro-cyclopenta[b]thiophen-4-one (0.9 g, 3.3 mmol) as brown solid in 45% yield.
  • 3
  • [ 5650-51-1 ]
  • [ 2905-65-9 ]
  • [ 1469858-09-0 ]
YieldReaction ConditionsOperation in experiment
45% With sodium hydride; In tetrahydrofuran; mineral oil; at 100℃; for 8h; 5,6-dihydro-cyclopenta [b] thiophen-4-one (2.1 g, 15.0 mmol) in 10 mL of THF was treated with NaH (60%, 0.73 g, 18 mmol).After the addition of 3-chloro-benzoic acid methyl ester, the reaction mixture was heated to 100 & lt; 0 & gt; C and maintained for 8 hours. The solution was cooled to room temperature and poured into water. The product mixture was acidified with concentrated hydrochloric acid and ethyl acetate (80 mL) was added. The organic layer was collected, treated with brine, dried over MgSO4 (s) and concentrated under reduced pressure. The resulting precipitate was collected and recrystallized from ethanol to give the corresponding 5- (4-chloro-benzoyl) -5,6-dihydro-cyclopenta [b] thiophen-4-one (0.9 g, 3.3 mmol) as a brown solid in 45% yield.
 

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