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Chemical Structure| 560082-51-1 Chemical Structure| 560082-51-1

Structure of 560082-51-1

Chemical Structure| 560082-51-1

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Product Details of [ 560082-51-1 ]

CAS No. :560082-51-1
Formula : C8H6FNO2
M.W : 167.14
SMILES Code : O=C1COC2=C(F)C=CC=C2N1
MDL No. :MFCD09835010

Safety of [ 560082-51-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 560082-51-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 560082-51-1 ]

[ 560082-51-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 560082-51-1 ]
  • [ 898832-40-1 ]
YieldReaction ConditionsOperation in experiment
87% With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Intermediate 8: 8-Fluoro-3,4-dihydro-2H-benzo[l,4]oxazineTo a stirred mixture of 8-fluoro-2H- l, 4-benzoxazin-3(4H)-one (l .Og, 0.0059mol) in THF (25mL) was added lithium aluminium hydride (7mL, 1M solution in THF) dropwise at 0°C to -5°C. The reaction mixture was stirred at room temperature for 2h and then poured onto ice and extracted with ethyl acetate. The organic phase was dried (MgS04) and the solvent removed under reduced pressure. The residue was triturated with diethyl ether to afford 8-fluoro-3,4-dihydro-2H-benzo[l,4]oxazine (0.8g, 87percent) as a dark brown solid.Mass: (ES+) 154 (M+H) + NMR: δΗ ( 6-DMSO) 3.27 (2H, m), 4.11 (2H, m), 6.05 (1H, br s), 6.34 (2H, m) and 6.58 (1H, m).
References: [1] Patent: WO2011/144578, 2011, A1, . Location in patent: Page/Page column 30.
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4700 - 4704.
 

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