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Chemical Structure| 56004-83-2 Chemical Structure| 56004-83-2

Structure of 56004-83-2

Chemical Structure| 56004-83-2
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Product Details of [ 56004-83-2 ]

CAS No. :56004-83-2
Formula : C8H11NS
M.W : 153.25
SMILES Code : NCC1=CC=CC=C1SC
MDL No. :MFCD00831039

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Application In Synthesis of [ 56004-83-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56004-83-2 ]

[ 56004-83-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 56004-83-2 ]
  • [ 3177-24-0 ]
  • [ 1214727-96-4 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 2h;Cooling with ice; Preparation Example 54 Under ice-cooling, to a solution of <strong>[3177-24-0]2,4-dichloropyrimidine-5-carbonitrile</strong> (1.00 g) in DMF (15 ml) were added dropwise a solution of 2-(methylthio)benzylamine (881 mg) in DMF (5 ml) and DIPEA (1.2 ml), followed by stirring at the same temperature for 1 hour. A solution of 2-(methylthio)benzylamine (44 mg) in DMF (2 ml) was added thereto, followed by stirring at room temperature for additional 1 hour. To the reaction mixture were added EtOAc and water, followed by liquid separation. The organic layer was sequentially washed with water and saturated brine, and dried over anhydrous magnesium sulfate. After the desiccant was removed, the solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (chloroform) to obtain 709 mg of 4-chloro-2-[2-(methylsulfanyl)benzyl]amino}pyrimidine-5-carbonitrile.
 

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