5585-96-6|4-Indolyl Acetate| Ambeed

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Quality Control of [ 5585-96-6 ] Purity: 98% SDS Specification

COA

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Product Details of [ 5585-96-6 ]

CAS No. :	5585-96-6
Formula :	C₁₀H₉NO₂
M.W :	175.18
SMILES Code :	CC(=O)OC1=C2C=CNC2=CC=C1
MDL No. :	MFCD00010678
InChI Key :	ZXDMUHFTJWEDEF-UHFFFAOYSA-N
Pubchem ID :	583934

Safety of [ 5585-96-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H317
Precautionary Statements:	P280

Computational Chemistry of [ 5585-96-6 ] Show Less

Physicochemical Properties

Num. heavy atoms	13
Num. arom. heavy atoms	9
Fraction Csp3	0.1
Num. rotatable bonds	2
Num. H-bond acceptors	2.0
Num. H-bond donors	1.0
Molar Refractivity	49.8
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	42.09 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.66
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.78
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.09
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	1.38
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.36
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.86

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-2.43
Solubility	0.654 mg/ml ; 0.00373 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.28
Solubility	0.915 mg/ml ; 0.00522 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-3.36
Solubility	0.0772 mg/ml ; 0.000441 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.1 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	1.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.48

Application In Synthesis of [ 5585-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 5585-96-6 ]

[ 5585-96-6 ] Synthesis Path-Downstream 1~35

1
[ 5585-96-6 ]
[ 2380-94-1 ]

References: [1]Journal of the Chemical Society,1948,p. 1605,1608.

2
[ 110-91-8 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 63065-87-2 ]

References: [1]Journal of Heterocyclic Chemistry,1977,vol. 14,p. 71 - 74.

3
[ 109-01-3 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 77872-37-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

4
[ 771-99-3 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 77872-35-6 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

5
[ 110-68-9 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 77872-29-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

6
[ 110-96-3 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 77872-24-3 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

7
[ 7713-69-1 ]
[ 79-37-8 ]
[ 5585-96-6 ]
[ 77872-31-2 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

8
[ 79-37-8 ]
[ 5585-96-6 ]
[ 2439-56-7 ]
[ 77872-33-4 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

9
[ 79-37-8 ]
[ 5585-96-6 ]
[ 626-23-3 ]
[ 77872-25-4 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

10
[ 79-37-8 ]
[ 5585-96-6 ]
[ 624-78-2 ]
[ 77872-26-5 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

11
[ 79-37-8 ]
[ 5585-96-6 ]
[ 4747-21-1 ]
[ 77872-28-7 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

12
[ 79-37-8 ]
[ 5585-96-6 ]
[ 14610-37-8 ]
[ 77872-32-3 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

13
[ 79-37-8 ]
[ 5585-96-6 ]
[ 625-43-4 ]
[ 77872-30-1 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

14
[ 79-37-8 ]
[ 5585-96-6 ]
[ 627-35-0 ]
[ 77872-27-6 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

15
[ 79-37-8 ]
[ 5585-96-6 ]
[ 3888-65-1 ]
[ 77872-36-7 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

16
[ 5585-96-6 ]
[ 73430-27-0 ]
[ 77872-52-7 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

17
[ 79-37-8 ]
[ 5585-96-6 ]
[ 124-40-3 ]
[ 30000-66-9 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

18
[ 79-37-8 ]
[ 5585-96-6 ]
[ 75-64-9 ]
[ 77872-22-1 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

19
[ 79-37-8 ]
[ 5585-96-6 ]
[ 103-49-1 ]
[ 77872-23-2 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

20
[ 79-37-8 ]
[ 5585-96-6 ]
[ 504-03-0 ]
[ 77872-34-5 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

23
2-acetoxy-6,β-dinitro-styrene [ No CAS ]
[ 5585-96-6 ]

References: [1]Journal of the Chemical Society,1948,p. 1605,1608.

24
[ 64-17-5 ]
acetic acid-[3-nitro-2-(2<i>t</i>-nitro-vinyl-(1<i>r</i>))-phenyl ester] [ No CAS ]
[ 64-19-7 ]
iron-turnings [ No CAS ]
[ 5585-96-6 ]

References: [1]Journal of the Chemical Society,1948,p. 1605,1608.

25
[ 2380-94-1 ]
[ 108-24-7 ]
[ 5585-96-6 ]

Yield	Reaction Conditions	Operation in experiment
99.2%	With pyridine; In dichloromethane; at 0 - 25℃;Inert atmosphere; Large scale;	4-hydroxyindole (1eq. limiting reagent) was charged to a vessel under N2 followed by DCM (dichloromethane; 6 vol based on 4-hydroxyindole charge). The reaction was cooled to 0-5C and pyridine added (1.2 eq) dropwise at 0-5C. Acetic anhydride (1.1 eq) was added dropwise at 0-5C and the reaction warmed to 20-25C for 1 - 1.5 hrs and stirred at 20-25C for a further 3 hours. The reaction was sampled and analysed for completion. The reaction was then washed three times with 20% aqueous citric acid solution (3 x 3 vol based on 4-hydroxyindole charge) and once with sat. NaHCC-3 (3 vol based on 4-hydroxyindole charge). The DCM solution was dried over MgSC and filtered and the DCM layer concentrated to half volume by distillation. Heptane (6 vol based on 4-hydroxyindole charge) was added and further DC was removed by distillation until full precipitation of the Stage 1 had occurred. The reaction was cooled to 15-25C and the solids collected by filtration, washing with heptane (1 vol based on 4-hydroxyindole charge) dried under vacuum overnight at 60C.

References: [1]Patent: WO2019/73379,2019,A1 .Location in patent: Paragraph 00237; 00276-00287.
[2]Journal of Medicinal Chemistry,2010,vol. 53,p. 18 - 36.
[3]Journal of Natural Products,2003,vol. 66,p. 885 - 887.

26
[ 79-37-8 ]
[ 5585-96-6 ]
[ 952006-34-7 ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; tert-butyl methyl ether; at 35 - 40℃;Large scale;	Stage 1 (1eq. limiting reagent) was charged to a vessel under N2 followed by THF (1 vol wrt stage 1 charge) and TBME (6 vol wrt stage 1 charge). Oxalyl chloride was then added dropwise to the vessel (1.5 eq,) allowing the exotherm to initially raise the temperature to 35- 40C and then applying cooling as required to maintain 35-40C. Immediately following the addition the reaction was heated to 40C and stirred for 2-6 hours. The reaction was sampled and analysed for completion, then cooled to RT and heptane (8 vol wrt stage 1 charge) added giving precipitation of further solids. The reaction was stirred for 10 min and then the solids were allowed to settle. The majority of the solvent was decanted from the solid which was then washed twice with heptane (2 x 6 vol wrt stage 1 charge), decanting in a similar manner after each wash. The solids were then sampled and analysed. TBME was charged to the vessel (4 vol wrt stage 1 charge) to give a yellow slurry which was cooled to - 20C using a dry ice/acetone bath. A 2M solution of Mue2NuEta in THF (2 eq,) was added dropwise to the vessel over ~15 min maintaining the temperature at -20C to -10C. The reaction mixture was allowed to warm slowly to RT and stirred overnight. Further Mue2NuEta can be added at this point if required. The reaction was sampled and analysed for completion. The reaction was filtered, washing with heptane (2 x 2 vol wrt stage 1 charge) and the isolated solids dried at 60C under vacuum. The crude stage 2 was slurried in water (8 vol wrt stage 1 charge) for 2-18 hours and then filtered, washing with water (2 vol wrt stage 1 charge). The solids were dried at 60C under vacuum to obtain crude stage 2 with <2% w/w water (determined by Karl Fischer titration (KF)). The crude stage 2 was slurried in IPA (10 vol) for 2-18 hrs and then filtered, washed with IPA (1 vol wrt mass of crude Stage 2) and oven dried under vacuum at 60C.

References: [1]Journal of Natural Products,2020.
[2]Journal of Natural Products,2003,vol. 66,p. 885 - 887.
[3]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 1977 - 1981.
[4]Patent: WO2019/73379,2019,A1 .Location in patent: Paragraph 00237; 00288-00325.

27
[ 5585-96-6 ]
[ 520-53-6 ]

References: [1]Journal of Natural Products,2003,vol. 66,p. 885 - 887.
[2]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.
[3]Patent: WO2019/73379,2019,A1 .

28
[ 5585-96-6 ]
[ 30000-66-9 ]

References: [1]Journal of Natural Products,2003,vol. 66,p. 885 - 887.
[2]Patent: WO2019/73379,2019,A1 .

29
[ 5585-96-6 ]
O,O-Dibenzylpsilocybin [ No CAS ]

References: [1]Journal of Natural Products,2003,vol. 66,p. 885 - 887.
[2]Patent: WO2019/73379,2019,A1 .

30
[ 5585-96-6 ]
[ 77872-41-4 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

31
[ 5585-96-6 ]
[ 77872-43-6 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

32
[ 5585-96-6 ]
[ 77872-47-0 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

33
[ 5585-96-6 ]
[ 77872-46-9 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

34
[ 5585-96-6 ]
[ 77872-45-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

35
[ 5585-96-6 ]
[ 77872-48-1 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 175 - 179.

Historical Records

Technical Information

• Acyl Group Substitution • Bouveault-Blanc Reduction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Ester Cleavage • Reactions with Organometallic Reagents • Specialized Acylation Reagents-Carbodiimides and Related Reagents

Related Functional Groups of
[ 5585-96-6 ]

Esters

A126457 [111258-23-2]

Methyl 4-methoxy-1H-indole-2-carboxylate

Similarity: 0.81

A109794 [5526-13-6]

7-Acetoxyindole

Similarity: 0.79

A155801 [98081-83-5]

Methyl 6-methoxy-1H-indole-2-carboxylate

Similarity: 0.78

A157907 [91-44-1]

7-(Diethylamino)-4-methyl-2H-chromen-2-one

Similarity: 0.76

A310663 [4792-58-9]

Ethyl5-methoxyindole-2-carboxylate

Similarity: 0.70

Related Parent Nucleus of
[ 5585-96-6 ]

Indoles

A194181 [37865-86-4]

6-Ethoxy-1H-indole

Similarity: 0.84

A129855 [3189-13-7]

6-Methoxyindole

Similarity: 0.81

A126457 [111258-23-2]

Methyl 4-methoxy-1H-indole-2-carboxylate

Similarity: 0.81

A164326 [169789-47-3]

5-Ethoxy-1H-indole-3-carbaldehyde

Similarity: 0.79

A109794 [5526-13-6]

7-Acetoxyindole

Similarity: 0.79

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Code	Phrase
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Response
Code	Phrase
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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P401
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P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 5585-96-6

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