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Chemical Structure| 55737-29-6 Chemical Structure| 55737-29-6

Structure of 55737-29-6

Chemical Structure| 55737-29-6

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Product Details of [ 55737-29-6 ]

CAS No. :55737-29-6
Formula : C7H3Cl2NO3
M.W : 220.01
SMILES Code : O=C(Cl)C1=CC=C([N+]([O-])=O)C(Cl)=C1
MDL No. :MFCD17779997

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Application In Synthesis of [ 55737-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55737-29-6 ]

[ 55737-29-6 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 58656-98-7 ]
  • [ 55737-29-6 ]
  • 3-(3-chloro-4-nitrobenzoyl)-4-fluorobenzoic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
1248 g With aluminum (III) chloride; In 1,2-dichloro-benzene; at 10 - 15℃; for 3h;Large scale; 816 g of the intermediate 2 was dissolved in 2500 g of o-dichlorobenzene, 900 g of aluminum trichloride was added, andthe o-dichlorobenzene solution of the intermediate 3 of the previous step was added dropwise to the reaction systemat 10-15 C. After the completion of the dropwise addition, thereaction was carried out at 10-15 C for about 3 hours.After the completion of the reaction, 2500 g of a 5.0% aqueous hydrochloric acid solution was added to the system, and the mixture was stirred for 10 minutes, allowed to stand for separation, and the organic phase was retained, and thesolvent was distilled off under reduced pressure at 100-120 C. O-dichlorobenzene was added to 2000 ethanol, heated to 75 C to dissolve, cooled to 0-5 C forcrystallization, and the filter cake was dried at 60 C to obtain 1248 g of intermediate 4.
 

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