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Chemical Structure| 55117-15-2
Chemical Structure| 55117-15-2

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1-Chloro-2-(chloromethyl)-3-fluorobenzene

CAS No.: 55117-15-2

4.5 *For research use only!

Cat. No.: A480433 Purity: 98%

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Product Details of [ 55117-15-2 ]

CAS No. :55117-15-2
Formula : C7H5Cl2F
M.W : 179.02
MDL No. :MFCD00000896
Boiling Point : No data available
InChI Key :MJGOLNNLNQQIHR-UHFFFAOYSA-N
Pubchem ID :108675

Safety of [ 55117-15-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis [ 55117-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55117-15-2 ]

[ 55117-15-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 55117-15-2 ]
  • [ 15205-15-9 ]
YieldReaction ConditionsOperation in experiment
With ammonia; In benzene; EXAMPLE 2 Preparation of 2 -Chloro-6 -fluorobenzylamine An autoclave was charged with 89.0 g. (0.5 mole) of 2-chloro-6-fluorobenzyl chloride, 170.0 g. (10 mole) ammonia and 50 ml. benzene. The reaction vessel was sealed and the contents heated at 100 C. for 15 hours. The excess ammonia was carefully evaporated off from the cooled contents of the autoclave with a stream of nitrogen. The residue was washed with water, and the organic phase after drying with anhydrous MgSO4, fractionated to afford 72.4 g. (90%) of product as a clear liquid; b.p. 99-100 C./20 mm; NMR (CDCl3) delta 1.46 (s, 2H); 3.88 (d, 2H); 7.00 (m, 3H).
  • 2
  • [ 117011-70-8 ]
  • [ 55117-15-2 ]
  • [ 1338359-21-9 ]
YieldReaction ConditionsOperation in experiment
~ 80% With potassium carbonate; In ethanol; for 24h;Reflux; Example 44-(2-chloro, 6-fluoro)benzylamino-phenoxyisobutyric acidA mixture of 1.28 ml (10 mole) of 2-chloro, 6-fluorobenzylchloride, 1.95 g (10 mole) <strong>[117011-70-8]4-aminophenoxyisobutyric acid</strong>, 2.76 g (20 mole) potassium carbonate and 25 ml ethanol was refluxed and stirred for 24 hours. The mixture was treated as in example 1 giving a solid with a melting point of 173-175 C. The structure (shown below as Formula EX4) was confirmed by NMR spectroscopy. The yield was approximately 80%
  • 3
  • [ 55117-15-2 ]
  • [ 5294-61-1 ]
  • 2-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)-N-(2,6- dimethylphenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With potassium carbonate; In acetonitrile; at 25℃; for 10.0h; General procedure: To a solution of <strong>[5294-61-1]N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide</strong> 4 in acetonitrile, different substituted benzyl chlorides 7a-e (0.001 mol) were slowly added drop wise in presence of K2CO3 (0.003 mol). Reaction mixture was stirred for 10 h at 25oC and completion of reaction was checked by TLC. Reaction mixture was poured into ice-cold water and extracted with methylene dichloride. The organic layers was washed with brine solution, dried over anhydrous sodium sulphate and concentrated to get alkylated piperazine derivatives 8a-e in good yield.
 

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