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Chemical Structure| 55095-26-6 Chemical Structure| 55095-26-6

Structure of 55095-26-6

Chemical Structure| 55095-26-6

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Product Details of [ 55095-26-6 ]

CAS No. :55095-26-6
Formula : C13H12FN
M.W : 201.24
SMILES Code : NC(C1=CC=CC=C1)C2=CC=C(C=C2)F
MDL No. :MFCD09026459
InChI Key :ABIODEXADJARAO-UHFFFAOYSA-N
Pubchem ID :11183272

Safety of [ 55095-26-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 55095-26-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 55095-26-6 ]

[ 55095-26-6 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 55095-26-6 ]
  • [ 88536-29-2 ]
  • [ 88535-75-5 ]
  • 3
  • Phenyl N-(4-fluorobenzhydryl)carbamate [ No CAS ]
  • [ 55095-26-6 ]
YieldReaction ConditionsOperation in experiment
64% With acetic acid; zinc; at 0 - 20℃; for 4.0h;Inert atmosphere; General procedure: To a stirred solution of (4-chlorophenyl) (pyridin-2-yl) methanone oxime (3.1 g, 13.36 mmol) in trifluoro acetic acid (20 mL) under argon atmosphere was added Zn-dust (2.6 g, 40.00mmol, 3 equiv) at 0 C. The reaction mixture was warmed to room temperature and stirred for4 h. After completion, the volatiles were removed under reduced pressure, the pH was adjusted to 8 with 10% NaHCO3 solution and extracted with EtOAc. The combined organic extract was dried over sodium sulfate, filtered and concentrated under reduced pressure to afford 2.18 g of (4-chlorophenyl) (pyridin-2-yl) methanamine (Yield = 75%).Ion trap: m/z 219.1 ([M + Hj). Title compound was prepared from (E)-(3-chlorophenyl)(pyridin-2-yl)methanone oxime(0.250 g, 1.07 mmol) using the conditions of step 4 in the general methodology of keyIntermediate-I and afforded 0.180 g of (2-chlorophenyl)(pyridin-2-yl)methanamine (Yield =77%).
  • 5
  • 4-fluorobenzhydrol [ No CAS ]
  • [ 55095-26-6 ]
  • 6
  • formyl succinonitrile potassium salt [ No CAS ]
  • [ 55095-26-6 ]
  • [ 648893-64-5 ]
YieldReaction ConditionsOperation in experiment
99.6% With acetic acid; In water; at 20 - 100℃; for 0.5h; (3) 2-([(4-Fluorophenyl) (phenyl)methyl]amino}methylene)butanedinitrile To a solution of formyl succinonitrile potassium salt (7.26 g, 49.7 mmol) and 1-(4-fluorophenyl)-1-phenylmethaneamine (11.0 g, 54.7 mmol) in water (20 ml) was added acetic acid (20 ml) at room temperature, the mixture was stirred at 100C for 30 minutes, and the solvent was distilled off under reduced pressure. The residue was poured into iced water, made basic by adding potassium carbonate and then extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give the objective product as a solid material. Yield (amount) 14.0 g, yield (rate) 99.6% 1H-NMR (CDCl3) δ: 3.12-3.17 (2H, m), 5.34-5.39 (1H, m), 5.55-5.58 (1H, m), 6.73-7.44 (10H, m). IR (KBr) cm-1; 3316, 2195, 1645, 1603, 1508, 1225, 1159, 833, 700.
  • 7
  • [ 127568-30-3 ]
  • [ 55095-26-6 ]
YieldReaction ConditionsOperation in experiment
99.1% (2) 1-(4-Fluorophenyl)-1-phenylmethaneamine A mixed solution of (4-fluorophenyl)(phenyl)methylformamide (13.1 g, 57.1 mmol), concentrated hydrochloric acid (80 ml) and methanol (160 ml) was stirred at 90C for 3 hours, cooled to room temperature, and then a 6 N aqueous sodium hydroxide solution (200 ml) was added thereto, which was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as oily matter. Yield (amount) 11.4 g, yield (rate) 99.1% 1H-NMR (CDCl3) δ: 5.20 (1H, s), 6.94-7.37 (9H, m). IR (KBr) cm-1; 3061, 1603, 1507, 1453, 1223, 1157, 843, 783, 700.
  • 8
  • [ 55095-26-6 ]
  • N-((4-fluorophenyl)(phenyl)methyl)acetamide [ No CAS ]
  • 9
  • [ 55095-26-6 ]
  • [ 137500-64-2 ]
  • 10
  • [ 55095-26-6 ]
  • [ 2493-02-9 ]
  • 1-(4-bromophenyl)-3-((4-fluorophenyl)(phenyl)methyl)urea [ No CAS ]
  • 11
  • [ 55095-26-6 ]
  • [ 345-83-5 ]
  • 12
  • [ 137500-64-2 ]
  • [ 55095-26-6 ]
  • 13
  • [ 100-47-0 ]
  • [ 55095-26-6 ]
 

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