Home Cart Sign in  
Chemical Structure| 5472-38-8 Chemical Structure| 5472-38-8

Structure of 5472-38-8

Chemical Structure| 5472-38-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 5472-38-8 ]

CAS No. :5472-38-8
Formula : C9H14O5
M.W : 202.20
SMILES Code : O=C(OCC)C(C=O)CC(OCC)=O
MDL No. :MFCD00056287

Safety of [ 5472-38-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 5472-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5472-38-8 ]

[ 5472-38-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 5472-38-8 ]
  • [ 867130-58-3 ]
  • 2
  • [ 1903-91-9 ]
  • [ 5472-38-8 ]
  • ethyl 2-methoxymethyl-4-hydroxypyrimidine-5-acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
43% In ethanol; Step 1, ethyl 2-methoxymethyl-4-hydroxypyrimidine-5-acetate Sodium metal (0.754 mol) was dissolved in absolute ethanol (100 ml) and the resulting solution was added dropwise to a solution of <strong>[1903-91-9]methoxyacetamidine hydrochloride</strong> (0.703 mol) in ethanol (100 ml). After 15 minutes the reaction mixture was filtered and the filtrate was added to a solution of diethyl formylsuccinate (0.703 mol), which was prepared according to H. Nakao et al. Ann. Sankyo Res. Lab., 18, 33-37 (1966). The reaction was refluxed for 15 hours, cooled to room temperature and was then concentrated to obtain a crude solid. This solid was crystallized from isopropanol to obtain the title compound (43% yield), m.p. 142-143 C. 1 H NMR (CDCl3): 7.85 (s, 1H), 4.4 (s, 2H), 4.2 (q, J=7.5 Hz, 2H), 3.5 (s, 3H), 3.4 (s, 2H), 1.2 (t, J=7.5 Hz, 3H).
  • 3
  • [ 3473-63-0 ]
  • [ 5472-38-8 ]
  • [ 6214-46-6 ]
YieldReaction ConditionsOperation in experiment
55% General procedure: A solution of sodium ethoxide in ethanol was cooled to0 C under argon atmosphere. Diethyl 2-formylsuccinatewas added under stirring. After 5 min, the correspondingamidine was added at 0 C and stirring was continued at rtfor 3 days. Aqueous hydrogen chloride solution (5 %) wasadded and it was stirred for 30 min. After addition of waterthe ethanol was removed in vacuo at 30 C. The precipitatewas filtered off to give compound 1 (X = H, Me, Ph, SMe;Y = H, R1 = Et)
 

Historical Records

Technical Information

Categories