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Chemical Structure| 5466-06-8 Chemical Structure| 5466-06-8

Structure of Ethyl 3-mercaptopropionate
CAS No.: 5466-06-8

Chemical Structure| 5466-06-8

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Product Details of [ 5466-06-8 ]

CAS No. :5466-06-8
Formula : C5H10O2S
M.W : 134.20
SMILES Code : O=C(OCC)CCS
MDL No. :MFCD00004896
InChI Key :CJQWLNNCQIHKHP-UHFFFAOYSA-N
Pubchem ID :21625

Safety of [ 5466-06-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H301+H331-H312-H410
Precautionary Statements:P210-P261-P264-P270-P271-P273-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P370+P378-P391-P403+P233-P403+P235-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 5466-06-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5466-06-8 ]

[ 5466-06-8 ] Synthesis Path-Downstream   1~6

  • 2
  • [ 5466-06-8 ]
  • [ 141403-49-8 ]
  • [ 148729-42-4 ]
  • 3
  • [ 5466-06-8 ]
  • [ 35737-10-1 ]
  • [ 76-05-1 ]
  • [ 193954-26-6 ]
  • [ 193954-28-8 ]
  • Fmoc-protected-β3-HTyr [ No CAS ]
  • H2N-β3-HAla-β3-HPh-β3-HTyr-HGly-S-ethylpropanoate trifluoroacetate [ No CAS ]
  • 4
  • [ 19745-07-4 ]
  • [ 5466-06-8 ]
  • ethyl 3-((5-chloropyrazin-2-yl)thio)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
6.98 g With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 18h; Intermediate 1 sodium 5-chloropyrazine-2-thiolate Step a: A mixture of <strong>[19745-07-4]2,5-dichloropyrazine</strong> (5 g, 33.6 mmol), K2CO3 (4.64 g, 33.6 mmol), and ethyl-3-mercaptopropanoate (4.45 mL, 35.1 mmol) in DMF (41.7 mL) was stirred for 18 h at RT. The reaction mixture was diluted with EtOAc (150 mL), was washed with water (2 x 50 mL), dried over Na2S04, filtered, and the volatiles were removed under reduced pressure. The resulting residue was purified by silica chromatography (0 to 5percent gradient of EtOAc/heptane) to give ethyl 3-((5-chloropyrazin-2-yl)thio)propanoate (6.98 g, 28.3 mmol). 'H NMR (400 MHz, Chloroform- ) delta ppm 8.39 (d, /=1.5 Hz, 1 H), 8.23 (d, 7=1.5 Hz, 1 H), 4.18 (q, 7=7.2 Hz, 2 H), 3.42 (t, 7=7.0 Hz, 2 H), 2.75 (t, 7=7.0 Hz, 2 H), 1.27 (t, 7=7.1 Hz, 3 H). MS m/z. 24 Lambda (M+H)+.
  • 5
  • [ 5466-06-8 ]
  • [ 5100-98-1 ]
  • ethyl 3-((2-chloro-6-methylphenyl)thio)propanoate [ No CAS ]
  • 6
  • [ 5466-06-8 ]
  • [ 5100-98-1 ]
  • ethyl 3-((2-chloro-6-(4-methoxybenzyl)phenyl)thio)propanoate [ No CAS ]
 

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