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Chemical Structure| 54584-24-6 Chemical Structure| 54584-24-6

Structure of 54584-24-6

Chemical Structure| 54584-24-6

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Product Details of [ 54584-24-6 ]

CAS No. :54584-24-6
Formula : C9H8O2
M.W : 148.16
SMILES Code : OC1=CC=C2C=C(C)OC2=C1
MDL No. :MFCD09908136

Safety of [ 54584-24-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 54584-24-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54584-24-6 ]

[ 54584-24-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 68500-37-8 ]
  • [ 54584-24-6 ]
  • 7-methoxy-4-(2-methyl-benzofuran-6-yloxy)-quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With caesium carbonate; In dimethyl sulfoxide; at 130℃; for 1.5h; To a degassed solution of 4-Chloro-7-methoxy-quinoline 125-C (76mg, 0. 39mmol) and 6- Hydroxy-2-methyl-benzofuran 125-B (58mg, 0. 39mmol) in 1. 5mi of dmso, was added Cesium Carbonate (320mg, 0. 98mmol). The reaction mixture was heated at 130 C for 1.5hr, cooled, poured into saturated aqueous NaCl solution, and extracted with with EtOAc and Et2O. The combined extracts washed again with saturated aqueous NaCI solution, dried (MgS04), and concentrated under reduced pressure. The residue was chromatographed on silica gel eluting a gradient of 9percent to 10percent of EtOAc in CH2CI2. In this manner 7-Methoxy-4- (2-methyl-benzofuran-6- yloxy)-quinoline 125 was prepared as a yellow solid (70mg, 58percent). 1H NMR (400 MHz, DMSO-D6) o ppm 8.57 (d, J=5.05 Hz, 1 H) 8.23 (d, J=9.35 Hz, 1 H) 7.62 (d, J=8.34 Hz, 1 H) 7.52 (d, J=1.77 Hz, 1 H) 7.40 (d, J=2. 53 Hz, 1 H) 7.28 (dd, J=9.09, 2.53 Hz, 1 H) 7.11 (dd, J=8.34, 2.02 Hz, 1 H) 6.65 (s, 1 H) 6.41 (d, J=5.31 Hz, 1 H) 3.93 (s, 3 H) 2.46 (s, 3 H). The biological activity of this compound is indicated by the following assay results: FLVK : 68percent inhibition 1uM ; FGF: 32percent inhibition 1 uM. See also the results shown in Table 1.
  • 2
  • [ 4265-25-2 ]
  • [ 54584-24-6 ]
  • [ 183812-30-8 ]
  • (+)-(2S,3R)-2,3-dihydroxy-2,3-dihydro-2-methyl[b]benzofuran [ No CAS ]
  • [ 1397698-20-2 ]
 

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