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Chemical Structure| 539-03-7 Chemical Structure| 539-03-7
Chemical Structure| 539-03-7
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Product Details of Paracetamol impurity J

CAS No. :539-03-7
Formula : C8H8ClNO
M.W : 169.61
SMILES Code : CC(NC1=CC=C(Cl)C=C1)=O
Synonyms :
4-Chloroacetanilide
MDL No. :MFCD00000612
InChI Key :GGUOCFNAWIODMF-UHFFFAOYSA-N
Pubchem ID :10871

Safety of Paracetamol impurity J

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P305+P351+P338

Application In Synthesis of Paracetamol impurity J

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 539-03-7 ]

[ 539-03-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 539-03-7 ]
  • [ 13519-75-0 ]
YieldReaction ConditionsOperation in experiment
70% With C20H25Cl2CoN3; sodium triethylborohydride; In 1,2-dimethoxyethane; at 100℃; for 6h;Inert atmosphere; Under an inert atmosphere, the substrate 4-chloroacetanilide (170 mg, 1 mmol), polymethylhydrosiloxane (668 μL, 3 mmol), Co-2 catalyst (9.0 mg, 0.02 mmol), sodium triethylborohydride (40 μL, 0.04 mmol)were sequentially added to the reaction tube and ethylene glycol dimethyl ether (2 mL), and the resulting mixture was stirred well.The reaction was carried out in an oil bath at 100C for 6 hours. The reaction system was cooled to room temperature, diluted and quenched by adding ethyl acetate, and concentrated. The crude product was subjected to flash silica gel column chromatography to obtain 109 mg of light yellow oily liquid, yield: 70%.
  • 2
  • [ 539-03-7 ]
  • [ 2873-89-4 ]
  • [ 74283-46-8 ]
  • [ 106-47-8 ]
  • [ 103-69-5 ]
  • [ 13519-75-0 ]
  • 4
  • [ 539-03-7 ]
  • [ 64-17-5 ]
  • [ 106-47-8 ]
  • [ 13519-75-0 ]
  • 5
  • [ 539-03-7 ]
  • [ 106-47-8 ]
  • [ 13519-75-0 ]
 

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