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Chemical Structure| 5339-59-3 Chemical Structure| 5339-59-3

Structure of 5339-59-3

Chemical Structure| 5339-59-3

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Product Details of [ 5339-59-3 ]

CAS No. :5339-59-3
Formula : C14H23NO2S
M.W : 269.40
SMILES Code : O=S(C1=CC=CC=C1)(N(CCCC)CCCC)=O
MDL No. :MFCD00151808
InChI Key :YKXINVWHNNYQMA-UHFFFAOYSA-N
Pubchem ID :220596

Safety of [ 5339-59-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 5339-59-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5339-59-3 ]

[ 5339-59-3 ] Synthesis Path-Downstream   1~10

  • 3
  • [ 109-65-9 ]
  • [ 98-10-2 ]
  • [ 5339-59-3 ]
YieldReaction ConditionsOperation in experiment
60% With copper(ll) bromide; In acetonitrile; at 50.0℃; for 12.0h; General procedure: Sulfonyl hydrazide (0.5 mmol) in a 50 mL round bottom flask equipped with a magnetic stir bar,CuBr2 (10 mol%, 0.05 mmol) and CH3CN (2.0 mL) were added.After adding amine (3 equiv, 1.5 mmol) and CH3CN (2.0 mL),The reaction mixture was stirred at 50 C. under air.After 12 hours, the mixture was diluted with the addition of EtOAc and quenched with a saturated aqueous solution of NH4Cl.The two layers were separated and the aqueous layer was extracted with EtOAc.The combined organic layer was dried over MgSO 4, filtered,Concentrated on a rotary evaporator.The residue was purified by column chromatography to obtain a sulfonamide product.
  • 5
  • [ 41483-67-4 ]
  • [ 71-43-2 ]
  • [ 5339-59-3 ]
  • 6
  • [ 5339-59-3 ]
  • [ 762-04-9 ]
  • [ 1450829-78-3 ]
  • 7
  • [ 1809-19-4 ]
  • [ 5339-59-3 ]
  • [ 1450829-79-4 ]
  • 8
  • [ 873-55-2 ]
  • [ 111-92-2 ]
  • [ 5339-59-3 ]
  • 9
  • [ 102-82-9 ]
  • [ 98-09-9 ]
  • [ 5339-59-3 ]
YieldReaction ConditionsOperation in experiment
72% With dipotassium hydrogenphosphate; oxygen; eosin y; In water; acetonitrile; at 20.0℃;Irradiation; Green chemistry; General procedure: To a 10 mL round bottom flask equipped with magnetic stirring bar was added4-toluenesulfonyl chloride 1a (0.2 mmol), triethylamine 2a (1 mmol), Eosin Y (3mol%), K2HPO4 (1.5 eq) and CH3CN/H2O (1/1, 6 mL). The solution was irradiatedwith 12 W Blue LEDs at room temperature in O2 atmosphere. After the completion ofthe reaction (indicated by TLC), the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica gel withpetroleum ether/ethyl acetate (5:1) to afford the desired pure product 4a.
  • 10
  • [ 111-92-2 ]
  • [ 80-17-1 ]
  • [ 5339-59-3 ]
YieldReaction ConditionsOperation in experiment
60% With copper(ll) bromide; In acetonitrile; at 50.0℃; for 12.0h; General procedure: To a 50 mL round-bottom flask equipped with a magnetic stir bar, sulfonyl hydrazide (0.5 mmol), CuBr2 (10 mol%, 0.05 mmol) and CH3CN (2.0 mL) was added. After amine (3 equiv, 1.5 mmol) and CH3CN (2.0 mL) were added, reaction mixture was stirred at 50 C under air. After 12 h, the mixture was diluted by adding EtOAc and quenched with a saturated aqueous solution of NH4Cl. Two layers were separated, and aqueous layer was extracted with EtOAc. The combined organic layer was dried over MgSO4, filtered, and concentrated on rotary evaporator. The residue was purified by column chromatography to give sulfonamide products.
 

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