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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 52431-78-4 Chemical Structure| 52431-78-4

Structure of 52431-78-4

Chemical Structure| 52431-78-4

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DEEPTI PANDEY ;

Abstract: Cancer continues to be a leading global health concern. Despite notable progress in current chemotherapeutics, drug resistance often contributes to treatment failure and poor prognosis. NF-κB signaling pathway has been long considered a prime regulator of normal biological processes and tumor cell survival, proliferation, and growth, which often contributes to resistant phenotypes. One reason for the resistance is the activation of DNA damage-induced canonical NF-κB that is transduced in part by interaction of CARP-1 protein with NF-κB activating kinase subunit gamma or NEMO. High throughput screening (HTS) of the chemical library yielded a selective NF-κB inhibitor (SNI)-1 that showed remarkable inhibition of CARP-1 and NEMO interaction in vitro, and consequent loss of canonical NF-κB activation that resulted in elevated cytotoxicity of chemotherapeutics adriamycin or cisplatin in vitro and in vivo. We aimed to synthesize and evaluate the selective NF-κB inhibitor (SNI)-1 analogs to improve their solubility, stability, and efficacy of cytotoxic chemotherapy. We are utilized Structure-Activity Relationship (SAR) strategies to identify a series of compounds. Several modifications and changes in specific moieties in SNI-1 were predicted to enhance compound drug-like properties such as solubility and biological activity. To date, we identified a few lead compounds that showed better potential to inhibit cell viability of different breast cancer cell lines compared to the parent compound. Our lead compounds GL-213, GL-216, GL-252, GL-269, and GL-340, GL-341, GL-342, and GL-343 have shown an effect on cell viability on their own, and in some instances, greater enhancement of chemotherapeutic efficacies in vitro assays. Thus, targeting of CARP-1 binding with NEMO has the potential to offer novel tools or strategies to combat various breast cancer and their drug-resistant variants. Outcomes of our current SAR studies are expected to identify additional potent drug-like lead compounds that will function in part by abrogating chemotherapy-induced NF-κB signaling activation and help minimize the development of drug-induced resistance and toxicities in breast cancers.

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Product Details of [ 52431-78-4 ]

CAS No. :52431-78-4
Formula : C7H6N4OS
M.W : 194.21
SMILES Code : S=C1NN=NN1C2=CC=C(O)C=C2
MDL No. :MFCD00132898

Safety of [ 52431-78-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H228
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:
 

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