Home Cart Sign in  
Chemical Structure| 52428-09-8 Chemical Structure| 52428-09-8

Structure of 52428-09-8

Chemical Structure| 52428-09-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 52428-09-8 ]

CAS No. :52428-09-8
Formula : C11H12O3
M.W : 192.21
SMILES Code : COC1=C2CCC(=O)C2=C(OC)C=C1
MDL No. :MFCD00757244
InChI Key :MSGQVFMAKBIPNF-UHFFFAOYSA-N
Pubchem ID :606012

Safety of [ 52428-09-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 52428-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52428-09-8 ]

[ 52428-09-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52428-09-8 ]
  • [ 24468-88-0 ]
  • [ 1419389-16-4 ]
YieldReaction ConditionsOperation in experiment
14.9% With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50℃; for 18h;Inert atmosphere; To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15 mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for 18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). The combined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2 (0.752 g, 14.9%). The compound was characterized by the following spectroscopic data: MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89 (m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).
14.9% With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50℃; for 18h;Inert atmosphere; To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). Thecombined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. Theresidue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2(0.752 g, 14.9%). The compound was characterized by the following spectroscopic data:MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89(m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 52428-09-8 ]

Aryls

Chemical Structure| 34985-41-6

A119393 [34985-41-6]

7-Methoxy-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 71846-67-8

A413964 [71846-67-8]

7-Methoxy-6-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 62358-78-5

A866719 [62358-78-5]

7-Methoxy-5-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 98154-04-2

A174864 [98154-04-2]

7-Hydroxy-4-methoxy-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 50919-86-3

A632447 [50919-86-3]

4-Methoxy-7-methyl-1H-indene-1,3(2H)-dione

Similarity: 1.00

Ethers

Chemical Structure| 67901-83-1

A477752 [67901-83-1]

7-Methoxy-4-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 71846-67-8

A413964 [71846-67-8]

7-Methoxy-6-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 62358-78-5

A866719 [62358-78-5]

7-Methoxy-5-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 98154-04-2

A174864 [98154-04-2]

7-Hydroxy-4-methoxy-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 50919-86-3

A632447 [50919-86-3]

4-Methoxy-7-methyl-1H-indene-1,3(2H)-dione

Similarity: 1.00

Ketones

Chemical Structure| 34985-41-6

A119393 [34985-41-6]

7-Methoxy-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 71846-67-8

A413964 [71846-67-8]

7-Methoxy-6-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 62358-78-5

A866719 [62358-78-5]

7-Methoxy-5-methyl-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 98154-04-2

A174864 [98154-04-2]

7-Hydroxy-4-methoxy-2,3-dihydro-1H-inden-1-one

Similarity: 1.00

Chemical Structure| 50919-86-3

A632447 [50919-86-3]

4-Methoxy-7-methyl-1H-indene-1,3(2H)-dione

Similarity: 1.00