52407-43-9|1-Benzofuran-3-ylacetonitrile| Ambeed

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Quality Control of [ 52407-43-9 ] Purity: 98% SDS Specification

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Product Details of [ 52407-43-9 ]

CAS No. :	52407-43-9
Formula :	C₁₀H₇NO
M.W :	157.17
SMILES Code :	N#CCC1=COC2=C1C=CC=C2
MDL No. :	MFCD02183555
InChI Key :	BJAJKVZABJZXDC-UHFFFAOYSA-N
Pubchem ID :	2769401

Safety of [ 52407-43-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H319
Precautionary Statements:	P305+P351+P338

Application In Synthesis of [ 52407-43-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 52407-43-9 ]

[ 52407-43-9 ] Synthesis Path-Downstream 1~35

1
[ 7169-34-8 ]
[ 2537-48-6 ]
[ 52407-43-9 ]

Yield	Reaction Conditions	Operation in experiment
66%	With hydrogenchloride; In tetrahydrofuran;	Step A: Preparation of 3-Cyanomethylbenzo[b]furan STR8 To a suspension of 27 gms (1.12 mole) of oil free sodium hydride in 400 ml of tetrahydrofuran (THF) was added dropwise a solution of 199.2 gms (1.12 mole) of diethylcyanomethylphosphonate in 400 mL of THF. After the H2 evolution had ceased, a solution of 150.1 g (1.12 mole) of 3-(2H)-benzo[b]-furanone in 1 L of THF was added. The solution was heated at 70 C. for 1.5 hours, cooled, and poured into 500 mL of 5% HCl, and washed with ether. The ether phase was washed with brine, dried (MgSO4), filtered and concentrated to give 15.4 g of a dark oil. The product was distilled at 110-120 C./0.7 Torr Hg to give 116 g (66% yield) of a yellow oil which crystallized upon standing.
	With hydrogenchloride; In tetrahydrofuran;	Step A: Preparation of 3-Cyanomethylbenzo[b]furan To a suspension of 2.64 grams (0.11 mole) of oil free sodium hydride in 200 milliliters of tetrahydrofuran (THF) was added dropwise a solution of 19.47 grams (0.11 mole) of diethyl cyanomethylphosphonate in 75 milliliters of THF. After the H2 evolution had ceased, a solution of 13.4 grams (0.1 mole) of 3-(2H)-benzo[b]furanone in 100 milliliters of THF was added. The solution was heated at 70 C. for 1.5 hours, cooled, and poured into 500 milliliters of 5% HCl, and worked up using conventional procedures and finally distilled at 96-100 C./0.075 mm Hg to obtain a yellow oil product which crystallized upon standing.
	With hydrogenchloride; In tetrahydrofuran;	Step A: Preparation of 3-Cyanomethylbenzo[b]furan To a suspension of 2.64 gms (0.11 mole) of oil free sodium hydride in 200 ml of tetrahydrofuran (THF) was added dropwise a solution of 19.47 gms (0.11 mole) of diethylcyanomethylphosphonate in 75 mL of THF. After the H2 evolution had ceased, a solution of 13.4 g (0.1 mole) of 3-(2H)-benzo[b]-furanone in 100 mL of THF was added. The solution was heated at 70 C. for 1.5 hrs, cooled, and poured into 500 mL of 5% HCl, and washed with ether. The ether phase was washed with brine, dried (MgSO4), filtered and concentrated to give 15.4 g of a dark oil. The product was distilled at 96-100 C./0.075 mm Hg to give 10.85 g of a yellow oil which crystallized upon standing.

	With hydrogenchloride; In tetrahydrofuran;	Step A: Preparation of 3-Cyanomethylbenzo[b]furan To a suspension of 2.64 gms (0.11 mole) of oil free sodium hydride in 200 ml of tetrahydrofuran (THF) was added dropwise a solution of 19.47 gms (0.11 mole) of diethylcyanomethylphosphonate in 75 mL of THF. After the H2 evolution had ceased, a solution of 13.4 g (0.1 mole) of 3-(2H)-benzo[b]furanone in 100 mL of THF was added. The solution was heated at 70 C. for 1.5 hours, cooled, and poured into 500 mL of 5% HCl, and washed with ether. The ether phase was washed with brine, dried (MgSO4), filtered and concentrated to give 15.4 g of a dark oil. The product was distilled at 96-100 C./0.075 mm Hg to give 10.85 g of a yellow oil which crystallized upon standing.
	With hydrogenchloride; In tetrahydrofuran;	Step A Preparation of 3-Cyanomethylbenzo[b]furan To a suspension of 2.64 grams (0.11 mole) of oil free sodium hydride in 200 milliliters of tetrahydrofuran (THF) was added dropwise a solution of 19.47 grams (0.11 mole) of diethyl cyanomethylphosphonate in 75 milliliters of THF. After the H2 evolution had ceased, a solution of 13.4 grams (0.1 mole) of 3-(2H)-benzo[b]furanone in 100 milliliters of THF was added. The solution was heated at 70 C. for 1.5 hours, cooled, and poured into 500 milliliters of 5% HCl, and worked up using conventional procedures and finally distilled at 96-100 C./0.075 mm Hg to obtain a yellow oil productwhich crystallized upon standing.
	With hydrogenchloride; In tetrahydrofuran;	Step A Preparation of 3-Cyanomethylbenzo[b]furan To a suspension of 2.64 gms (0.11 mole) of oil free sodium hydride in 200 ml of tetrahydrofuran (THF) was added dropwise a solution of 19.47 gms (0.11 mole) of diethylcyanomethylphosphonate in 75 mL of THF. After the H2 evolution had ceased, a solution of 13.4 g (0.1 mole) of 3-(2H)-benzo[b]furanone in 100 mL of THF was added. The solution was heated at 70 C. for 1.5 hours, cooled, and poured into 500 mL of 5% HCl, and washed with ether. The ether phase was washed with brine, dried (MgSO4), filtered and concentrated to give 15.4 g of a dark oil. The product was distilled at 96-100 C./0.075 mm Hg to give 10.85 g of a yellow oil which crystallized upon standing.

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.
[2]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.
[3]Patent: US4835276,1989,A .
[4]Journal of Medicinal Chemistry,1992,vol. 35,p. 1176 - 1183.
[5]Journal of Organic Chemistry,2004,vol. 69,p. 5302 - 5306.
[6]Patent: US4916223,1990,A .
[7]Patent: US4673680,1987,A .
[8]Patent: US4710504,1987,A .
[9]Patent: US4831035,1989,A .
[10]Patent: US4690928,1987,A .

2
[ 52407-43-9 ]
[ 27404-31-5 ]

Yield	Reaction Conditions	Operation in experiment
71%	aluminum nickel; In methanol;	Step B: Preparation of 2-(3-benzo[b]furanyl)ethylamine STR9 To a solution of 3.1 g of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 40 mL of methanol was added 2.4 g of Raney nickel. The reaction was agitated at 25 C. in a Parr apparatus under 40 psi hydrogen for 21/2 hours. The suspension was filtered through a pad of filter aid and the filtrate was evaporated to give 2.2 g (71% yield) of oily product.
	In diethyl ether; water;	Step B: Preparation of 2-(3-benzo[b]furanyl)ethylamine A solution of 3.97 grams (0.025 mole) of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 200 milliliters of diethyl ether was slowly added to a refluxing suspension of 3.84 grams (0.1 mole) of lithium aluminum hydride in 400 milliliters of ether and the mixture was heated 3 hours, then cooled and water was slowly added. The suspension was filtered and the filtrate was evaporated to obtain an oily product, the hydrochloride salt of which has m.p. 183-185 C.
	In diethyl ether; water;	Step B: Preparation of 2-(3-benzo[b]furanyl)ethylamine A solution of 3.97 g (0.025 mole) of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 200 mL of diethyl ether was slowly added to a refluxing suspension of 3.84 g (0.1 mole) of lithium aluminum hydride in 400 mL of ether. The reaction was heated 3 hrs., cooled and water was slowly added. The suspension was filtered through a pad of filter aid and the filtrate was evaporated to give 3.2 g of oily product. The hydrochloride salt has m.p. 183-185 C.

	In diethyl ether; water;	Step B: Preparation of 2-(3-benzo[b]furanyl)ethylamine A solution of 3.97 g (0.025 mole) of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 200 mL of diethyl ether was slowly added to a refluxing suspension of 3.84 g (0.1 mole) of lithium aluminum hydride in 400 mL of ether. The reaction was heated 3 hours., cooled and water was slowly added. The suspension was filtered through a pad of filter aid and the filtrate was evaporated to give 3.2 g of oily product. The hydrochloride salt has m.p. 183-185 C.
	In diethyl ether; water;	Step B Preparation of 2-(3-benzo[b]furanyl)ethylamine A solution of 3.97 grams (0.025 mole) of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 200 milliliters of diethyl ether was slowly added to a refluxing suspension of 3.84 grams (0.1 mole) of lithium aluminum hydride in 400 milliliters of ether and the mixture was heated 3 hours, then cooled and water was slowly added. The suspension was filtered and the filtrate was evaporated to obtain an oily product, the hydrochloride salt of which has m.p. 183-185 C.
	In diethyl ether; water;	Step B Preparation of 2-(3-benzo[b]furanyl)ethylamine A solution of 3.97 g (0.025 mole) of <strong>[52407-43-9]3-cyanomethylbenzo[b]furan</strong> in 200 mL of diethyl ether was slowly added to a refluxing suspension of 3.84 g (0.1 mole) of lithium aluminum hydride in 400 mL of ether. The reaction was heated 3 hours., cooled and water was slowly added. The suspension was filtered through a pad of filter aid and the filtrate was evaporated to give 3.2 g of oily product. The hydrochloride salt has m.p. 183-185 C.
		A. In a manner similar to that described in Step D of Example 32, but replacing 2-(1-tert-butoxycarbonyl indol-3-yl) propionitrile with 3-benzofuranylacetonitrile, the intermediate 3(2-aminoethyl) benzofuran was prepared; MS (ES): 162 (MH+).

References: [1]Patent: US4835276,1989,A .
[2]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.
[3]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.
[4]Patent: US4916223,1990,A .
[5]Patent: US4686226,1987,A .
[6]Patent: US4710504,1987,A .
[7]Patent: US4831035,1989,A .
[8]Patent: US4690928,1987,A .
[9]Patent: US2005/54634,2005,A1 .

3
[ 52407-43-9 ]
[ 64175-51-5 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

4
[ 52407-43-9 ]
[ 139313-76-1 ]

References: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 1176 - 1183.

5
[ 40052-96-8 ]
[ 372-09-8 ]
[ 52407-43-9 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

Yield	Reaction Conditions	Operation in experiment
91%		Preparation 129 1-Benzofuran-3-ylacetonitrile Sodium hydride (268 mg, 6.7 mmol) was slurried in dry THF (10 ml) at 0 C. under nitrogen and diethyl cyanomethyl phosphonate (1.1 ml, 6.7 mmol) added dropwise and the whole stirred for 45 min. 3-Coumaranone (Lancaster) (900 mg, 6.7 mmol) was then added dropwise and the whole stirred at room temperature for 45 min. The reaction was diluted with EtOAc (15 ml) and water (15 ml), and the organic layer was then separated, dried (MgSO4) and evaporated and the residue flash chromatographed using 0-5% EtOAc in pentane to give the title product (940 mg, 91%); 1H-NMR (400 MHz, CDCl3) δ: 3.77 (s, 2H), 7.25-7.40 (m, 2H), 7.52 (dd, 1H), 7.58 (dd, 1H), 7.67 (s, 1H); LRMS: M+NH4+, 175. (TS+).
		Preparation 130 2-(1-Benzofuran-3-yl)-ethylamine The product from Preparation 129 (400 mg, 2.55 mmol) was combined with ammonium hydroxide solution (10 ml), ethanol (20 ml) and 30wt % Ra-Ni (120 mg, cat.) and hydrogenated at 30p.s.i. hydrogen pressure at room temperature for 16 h.
116 g (66%)		Step A: Preparation of 3-Cyanomethylbenzo[b]furan STR8 NaH (54 g of a 50% oil suspension; 1.12 mol) was placed in a 3 L 3-neck RB flask equipped with a mechanical stirrer and washed twice with hexane. Dry THF (400 ml) was added followed by the dropwise addition of a solution of diethylcyanomethyl phosphonate (199.2 g; 1.12 mol) in 400 ml of THF. After the addition was complete, the reaction was stirred an additional 30 minutes until gas evolution ceased. A solution of 1 (150.1 g; 1.12 mol) in 1 L of THF was added dropwise at room temperature. The reaction was refluxed for 1.5 hours. After cooling, the solvent was removed in vacuo. The residue was dissolved in ether and acidified with concentrated HCl. The ether layer was washed with 6N HCl (3*300 ml), H2 O, brine, dried (Na2 SO4), filtered, and concentrated. The crude product was distilled to afford 116 g (66%) of 2 b.p. (0.7 Torr) 110-120 C.

8
[ 52407-43-9 ]
N-2-(benzo[b]furan-3-yl)ethylamine hydrochloride [ No CAS ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.

9
[ 52407-43-9 ]
(2-fluoro-2-hydrobenzofuran-3-ylidene)acetonitrile [ No CAS ]
trans-(2,3-difluoro-2,3-dihydro-3-benzofuranyl)acetonitrile [ No CAS ]
cis-(2,3-difluoro-2,3-dihydro-3-benzofuranyl)acetonitrile [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 5302 - 5306.
[2]Journal of Organic Chemistry,2004,vol. 69,p. 5302 - 5306.

10
[ 52407-43-9 ]
(2-fluoro-2-hydrobenzofuran-3-ylidene)acetonitrile [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 5302 - 5306.

11
[ 52407-43-9 ]
<i>N</i>-(2-benzofuran-3-yl-ethyl)-acrylamide [ No CAS ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.

12
[ 52407-43-9 ]
N-[2-(benzo[b]furan-3-yl)ethyl]vinylacetamide [ No CAS ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.

13
[ 52407-43-9 ]
N-[2-(benzo[b]furan-3-yl)ethyl]phenylacetamide [ No CAS ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.

14
[ 52407-43-9 ]
<i>N</i>-(2-benzofuran-3-yl-ethyl)-2-(3,4-dichloro-phenyl)-acetamide [ No CAS ]

References: [1]Pharmacy and Pharmacology Communications,1999,vol. 5,p. 177 - 181.

15
[ 52407-43-9 ]
[ 97456-65-0 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

16
[ 52407-43-9 ]
[ 98678-87-6 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

17
[ 52407-43-9 ]
[ 100480-86-2 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

18
[ 52407-43-9 ]
[ 100480-87-3 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

19
[ 52407-43-9 ]
[ 98678-88-7 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

20
[ 52407-43-9 ]
[ 98678-89-8 ]

References: [1]Journal of Medicinal Chemistry,1985,vol. 28,p. 1756 - 1759.

21
[ 52407-43-9 ]
[ 128104-98-3 ]

References: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 1176 - 1183.

22
[ 7169-34-8 ]
[ 52407-43-9 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

23
[ 52407-43-9 ]
[ 63703-24-2 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

24
[ 52407-43-9 ]
[ 82156-58-9 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

25
[ 52407-43-9 ]
[ 75611-06-2 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

26
[ 52407-43-9 ]
[ 136229-40-8 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

27
[ 52407-43-9 ]
[ 136229-46-4 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.
[2]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

28
[ 52407-43-9 ]
[ 136229-44-2 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

29
[ 52407-43-9 ]
[ 136229-43-1 ]

References: [1]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.
[2]Australian Journal of Chemistry,1991,vol. 44,p. 907 - 917.

30
[ 52407-43-9 ]
[ 4435-14-7 ]
[ 128104-98-3 ]

Yield	Reaction Conditions	Operation in experiment
		Step (2) Preparation of 4-[(3-Benzofuranyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-Oxide According to Scheme I illustrated by Example 4, 3-benzofuranylacetonitrile was converted to the desired product as beige crystals, m.p. 138.5-140 C. temperature. Cyclohexylacetonitrile (14.7 g, 120 mmol) was added in one portion and the resulting mixture was heated to reflux for 12 hours. The mixture was cooled to room temperature and concentrated to give a yellow solid. The solid was collected by filtration, washed with water, EtOAc/hexane (2:8), and dried in vacuo to give 7.4 g (40%) of the product of sufficient purity for use in the next reaction. NMR (DMSO-d6, 200 MHz): delta 0.85 (m, 2H), 1.10 (m, 3H), 1.64 (m, 6H), 1.80 (d, J=7.0, 2H), 5.25 (br s, 2H), 8.30 (br s, 1H).

References: [1]Patent: US4895860,1990,A .

31
[ 2537-48-6 ]
[ 52407-43-9 ]

Yield	Reaction Conditions	Operation in experiment
6.67 g (100%)	In tetrahydrofuran; hexane;	Step (1) Preparation of 3-Benzofuranylacetonitrile To a stirred mixture of hexane washed sodium hydride (2.21 g, 0.046 mol, 50%/mineral oil) in THF (125 mL), was added diethyl cyanomethylphosphonate (8.15 g, 0.046 mol) dropwise. The reaction was stirred at room temperature for 1/2 hour, 3-coumaranone (sublimed) (5.6 g, 0.042 mol) in THF (100 mL) was added dropwise at 0 C., and the reaction mixture was stirred at room temperature overnight. The mixture was diluted with water (300 mL), and extracted with ether (800 mL). The extracts were washed with brine (2*100 mL), dried (MgSO4), and concentrated to yield 6.67 g (100%) of the product as an off-white solid. NMR (CDCl3, 200 MHz): δ 3.77 (s, 2H), 7.2-7.9 (m, 5H).

References: [1]Patent: US4895860,1990,A .

32
[ 52407-43-9 ]
[ 187804-19-9 ]

Yield	Reaction Conditions	Operation in experiment
75%	With hydrogenchloride; In tert-butyl alcohol;	Referential Example 16 To a solution of <strong>[52407-43-9]benzofuran-3-acetonitrile</strong> (120 mg, 0.76 mmol) synthesised according to a known method (J. Med. Chem.,Vol. 35, p. 1176, 1992) in tert-butyl alcohol (2 mL) was added potassium hydride (340 mg, 6.08 mmol), and the whole was refluxed for 1.5 hours. After cooling to room temperature and acidification with 1N hydrochloric acid, resulting solid was filtrated, washed with water and diethyl ether gave benzofuran-3-acetamide (100 mg, 75%) as brown solid. 1H NMR(DMSO-d6) δ 3. 48(s, 2H), 6. 98(brs, 1H), 7. 25(t, J=7. 4Hz, 1H), 7. 31(t, J= 7. 4Hz, 1H), 7. 53(brs, 1H), 7. 54 (d, J=7. 4Hz, 1H), 7.63(d, J=7. 4Hz, 1H), 7. 81(s, 1H). IR(KBr) 3355, 3200, 1665, 1640, 1460, 1420, 1410, 1100, 755cm-1. MS m/z 175(M+)

References: [1]Patent: EP1224932,2002,A1 .

33
[ 500-22-1 ]
[ 52407-43-9 ]
(Z)-2-(benzo[b]furan-3-yl)-3-(pyridin-4-yl)acrylonitrile [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2010,vol. 49,p. 8228 - 8231.

34
[ 52407-43-9 ]
[ 1449744-25-5 ]

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 12576 - 12579.

35
[ 52407-43-9 ]
[ 1449744-09-5 ]

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 12576 - 12579.

Historical Records

Technical Information

• Blaise Reaction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Hydride Reductions • Preparation of Aldehydes and Ketones • Preparation of Amines • Ritter Reaction • Thorpe-Ziegler Reaction

Related Functional Groups of
[ 52407-43-9 ]

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Related Parent Nucleus of
[ 52407-43-9 ]

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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 52407-43-9

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