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Chemical Structure| 52011-76-4 Chemical Structure| 52011-76-4

Structure of 52011-76-4

Chemical Structure| 52011-76-4

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Product Details of [ 52011-76-4 ]

CAS No. :52011-76-4
Formula : C10H7ClO4
M.W : 226.61
SMILES Code : O=C(C1CC(C2=C(O1)C=CC(Cl)=C2)=O)O
MDL No. :MFCD09262300

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52011-76-4 ]

[ 52011-76-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52011-76-4 ]
  • [ 40026-24-2 ]
YieldReaction ConditionsOperation in experiment
90% c) (R,S)-6-Chloro-chroman-2-carboxylic acid (9c) To a stirred suspension of compound 9b (1.13 g, 5 mmol) in trifluoroacetic acid (5 mL) was added dropwise triethylsilane (2.4 mL, 12.5 mmol). The mixture was stirred at 55 C. for three days. After cooled down to 25 C., the excess triethylsilane and solvent were removed under reduced pressure and the residue was dissolved in 1N sodium hydroxide. The aqueous solution was washed with ethyl ether, acidified with 6N hydrogen chloride acid until pH~1, and extracted with ethyl acetate. The combined extracts were washed with water, brine, dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure, and dried in vacuo to afford 0.95 g (90%) of the title compound. 1H NMR (300 MHz, DMSO-d6) delta 13.08 (b, 1H), 7.15 (m, 2H), 6.86 (d, 1H), 4.83 (t, 1H), 2.82 (m, 1H), 2.76 (m, 1H), 2.11 (m, 2H).
 

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