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Chemical Structure| 51848-56-7 Chemical Structure| 51848-56-7

Structure of 51848-56-7

Chemical Structure| 51848-56-7

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Product Details of [ 51848-56-7 ]

CAS No. :51848-56-7
Formula : C17H16O4
M.W : 284.31
SMILES Code : O=C(OCC)COC1=CC=C(C(C2=CC=CC=C2)=O)C=C1
MDL No. :MFCD03699741
Boiling Point : No data available

Safety of [ 51848-56-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 51848-56-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 51848-56-7 ]
  • Downstream synthetic route of [ 51848-56-7 ]

[ 51848-56-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 51848-56-7 ]
  • [ 6322-83-4 ]
YieldReaction ConditionsOperation in experiment
74%
Stage #1: With sodium hydroxide In ethanol at 20℃;
Stage #2: With hydrogenchloride In water at 0℃;
General procedure: A solution of NaOH 1N (3.9 mmol) was added to esters 7-16(3.0 mmol) in EtOH (20 mL), and the mixture was stirred at r.t. for 10-15 h. The solvent was removed under reducedpressure and the residue was poured into water (20 mL) andacidified with conc HCl at 0 °C. The aqueous layer was extractedwith dichloromethane (3 20 mL) and then the organiclayer was dried over Na2SO4 and concentrated underreduced pressure. The residue was purified by crystallizationwith cyclohexane or chloroform affording desired acids 17-26 with good yields.
References: [1] Medicinal Chemistry, 2014, vol. 10, # 1, p. 59 - 65.
[2] Anales de la Real Sociedad Espanola de Fisica y Quimica, vol. 24, p. 88[3] Chemisches Zentralblatt, 1926, vol. 97, # II, p. 21.
[4] Tetrahedron Letters, 2004, vol. 45, # 10, p. 2239 - 2241.
[5] Journal of Peptide Science, 2010, vol. 16, # 10, p. 551 - 557.
 

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