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Chemical Structure| 51785-22-9 Chemical Structure| 51785-22-9

Structure of 51785-22-9

Chemical Structure| 51785-22-9

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Product Details of [ 51785-22-9 ]

CAS No. :51785-22-9
Formula : C12H14N2S
M.W : 218.32
SMILES Code : C1(C2NCCCC2)=NC3=CC=CC=C3S1
MDL No. :MFCD05190089
InChI Key :QXJHTXUNRZNJKT-UHFFFAOYSA-N
Pubchem ID :3327259

Safety of [ 51785-22-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 51785-22-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51785-22-9 ]

[ 51785-22-9 ] Synthesis Path-Downstream   1~6

  • 3
  • [ 1203605-21-3 ]
  • [ 51785-22-9 ]
  • [ 1203604-51-6 ]
YieldReaction ConditionsOperation in experiment
37% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85℃;Inert atmosphere; Under argon, a solution of 3-chloro-5-(2,6-dimethoxyphenyl)-1,2,4-triazine (15.4 mg, 0.061 mmol, prepared as in example 41), <strong>[51785-22-9]2-piperidin-2-yl-1,3-benzothiazole</strong> (20 mg, 0.092 mmol) and DIPEA (11 µL, 0.063 mmol) in anhydrous acetonitrile (0.25 mL) was stirred at 85C overnight. The solution was then concentrated and the residue was purified by preparative TLC (silica gel, dichloromethane/methanol 95/5) to give 2-{1-[5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-yl]piperidin-2-yl}-1,3-benzothiazole (9.8 mg, 37%) as a yellow oil. ESI-MS m/z 434 (M+H)+. 1H NMR (CDCl3), δ (ppm): 8.59 (s, 1H), 7.99 (d, J = 7.8 Hz, 1H), 7.83 (d, J = 7.8 Hz, 1H), 7.45 (t, J = 8.4 Hz, 1H), 7.39-7.32 (m, 2H), 7.60 (d, J = 8.4 Hz, 2H), 6.55 (br s, 1H), 5.04-5.00 (m, 1H), 3.67 (s, 6H), 3.36-3.28 (m, 1H), 2.79-2.74 (m, 1H), 2.06-2.02 (m, 1H), 1.80-1.69 (m, 4H).
  • 4
  • C19H13BrFNOS [ No CAS ]
  • [ 51785-22-9 ]
  • C31H27BrFN3OS2 [ No CAS ]
  • 5
  • C18H23NO2 [ No CAS ]
  • [ 51785-22-9 ]
  • C30H37N3O2S [ No CAS ]
  • 6
  • C20H21NO4 [ No CAS ]
  • [ 51785-22-9 ]
  • C32H35N3O4S [ No CAS ]
 

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